Author

T. Krey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Organism:non-human primate· 1

Frequent Co-Authors

B. Correia· 2 shared C. Yang· 2 shared F. Sesterhenn· 2 shared J. Bonet· 2 shared J. Cramer· 2 shared L. Abriata· 2 shared S. Georgeon· 2 shared S. Rosset· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

B. Correia

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Viral modulation of type II interferon increases T cell adhesion and virus spread

C. Juergens, G. Ssebyatika, S. Beyer, N. Plueckebaum, K. Kropp, V. Gonzalez-Motos, B. Ritter, H. Boening, E. Nikolouli, P. R. Kinchington, N. Lachmann, D. Depledge, T. Krey, A. Viejo-Borbolla

This study shows that VZV glycoprotein C modulates IFN-γ activity, increasing ICAM1 expression and T cell adhesion, which enhances virus spread from epithelial cells to lymphocytes.

bioRxiv · May 26, 2023 · PreprintMicrobiology

A Hepatitis C virus genotype 1b post transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo

C. Heuss, P. Rothhaar, R. Burm, J.-Y. Lee, U. Haselmann, L. J. Ströh, P. Ralfs, O. Colasanti, C. S. Tran, N. Schäfer, P. Schnitzler, U. Merle, R. Bartenschlager, A. H. Patel, F. Graw, , V. Lohmann

This paper develops an efficient HCV genotype 1b infectious cell culture model through adaptation, enabling vaccine development and understanding viral evolution post-transplant.

bioRxiv · Mar 28, 2022Microbiology

A bottom-up approach for the de novo design of functional proteins

C. Yang, F. Sesterhenn, J. Bonet, E. v. Aalen, L. Scheller, L. Abriata, J. Cramer, X. Wen, S. Rosset, S. Georgeon, T. S. Jardetzky, T. Krey, M. Fussenegger, M. Merkx, B. Correia

This paper introduces a bottom-up method for designing functional proteins tailored to complex motifs, demonstrating their use as biosensors and signaling ligands.

bioRxiv · Mar 11, 2020 · PreprintBioengineering

De novo protein design enables precise induction of functional antibodies in vivo

F. Sesterhenn, C. Yang, J. Cramer, J. Bonet, X. Wen, L. Abriata, I. Kucharska, C.-I. Chiang, Y. Wang, G. Castoro, S. Vollers, M. Galloux, R. Charles-Adrien, E. Dheilly, S. Rosset, , B. Correia

This paper introduces a de novo protein design algorithm called TopoBuilder that generates immunogens inducing precise antibody responses against respiratory syncytial virus in mice and non-human primates.

bioRxiv · Feb 14, 2020 · PreprintBioengineering