Intranasal self-amplifying RNA SARS-CoV-2 vaccine produces protective respiratory and systemic immunity and prevents viral transmission
M. F. Jennewein, M. D. Schultz, S. Beaver, P. Battisti, J. Bakken, D. Hanson, J. Akther, F. Zhou, R. Mohamath, J. Singh, N. Cross, D. N. Kasal, M. Ykema, S. Reed, D. Kalange, , E. A. Voigt
This study compares intranasal and intramuscular delivery of a self-amplifying RNA SARS-CoV-2 vaccine, showing that intranasal delivery induces mucosal immunity and reduces viral transmission.
bioRxiv · Nov 10, 2022 · PreprintImmunology