Upregulated PD-1 Signaling is an Important Antagonist to Glomerular Health in Aged Kidneys
J. W. Pippin, N. Kaverina, Y. Wang, D. Eng, Y. Zeng, U. Tran, C. J. Loretz, A. Chang, C. O'Connor, M. Bitzer, O. Wessely, S. J. Shankland
This study shows that upregulated PD-1 signaling in aged kidneys impairs podocyte health and that anti-PD-1 treatment improves podocyte aging and kidney function.
bioRxiv · Oct 26, 2021 · PreprintCell Biology