Evaluation of pneumococcal serotyping in nasopharyngeal carriage isolates by latex agglutination, whole genome sequencing (PneumoCaT) and DNA microarray in a high pneumococcal carriage prevalence population in Malawi
T. D. Swarthout, A. Gori, N. Bar-Zeev, A. W. Kamng'ona, T. S. Mwalukomo, F. Bonomali, R. Nyirenda, C. Brown, J. Msefula, D. Everett, C. Mwansambo, K. Gould, J. Hinds, R. Heyderman, N. French
The paper evaluates three pneumococcal serotyping methods in Malawi, finding high concordance between latex agglutination, whole genome sequencing, and DNA microarray, with microarray improving detection of low-abundance vaccine serotypes.
bioRxiv · Aug 17, 2020Microbiology