Expansion of pneumococcal serotype 23F and 14 lineages with genotypic changes in capsule polysaccharide locus and virulence gene profiles post introduction of pneumococcal conjugate vaccine in Blantyre, Malawi
R. Cave, A. Kalizang'oma, C. Chaguza, T. S. Mwalukomo, A. Kamng'ona, C. Brown, J. Msefula, F. Bonomali, R. Nyirenda, T. D. Swarthout, B. Kwambana-Adams, N. French, R. S. Heyderman
The paper analyzes whole-genome sequences of pneumococcal isolates in Malawi to show expansion of vaccine serotype lineages with genetic changes in capsule and virulence genes post-PCV13 introduction.
bioRxiv · Mar 25, 2024Microbiology