BioengineeringbioRxiv
Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
X. Chen, D. A. Wolfe, D. Sivadasan Bindu…·V. Gradinaru
The paper develops AAV vectors with endothelial-specific tropism for brain delivery in rodents and broad tropism in primates, demonstrating their utility in genetic engineering of the blood-brain barrier.