Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates
X. Chen, D. A. Wolfe, D. Sivadasan Bindu, M. Zhang, N. Taskin, D. Goertsen, T. F. Shay, E. Sullivan, S. Ravindra Kumar, S.-F. Huang, C. M. Arokiaraj, V. Plattner, L. J. Campos, J. K. Mich, D. Monet, , V. Gradinaru
The paper develops AAV vectors with endothelial-specific tropism for brain delivery in rodents and broad tropism in primates, demonstrating their utility in genetic engineering of the blood-brain barrier.
bioRxiv · Jan 12, 2023Bioengineering