D. Gur

Controlled pH Alteration Enables Guanine Accumulation and Drives Crystallization within Iridosomes

The paper investigates the role of pH changes in guanine accumulation and crystallization within zebrafish iridosomes, showing that acidic conditions and V-ATPase activity drive crystal formation.

Biogenic plate-like guanine crystals form via templated nucleation of thin crystal leaflets on amyloid scaffolds

The paper shows that biogenic plate-like guanine crystals form through templated nucleation on amyloid scaffolds in zebrafish larvae.

Phage therapy potentiates second-line antibiotic treatment against pneumonic plague

This paper shows that combining phage therapy with ceftriaxone improves survival in a mouse model of pneumonic plague caused by multidrug-resistant Yersinia pestis.

Monitoring group activity of hamsters and mice as a novel tool to evaluate COVID-19 progression, convalescence and rVSV-ΔG-spike vaccination efficacy

This study uses group activity monitoring in hamsters and mice to assess SARS-CoV-2 infection, convalescence, and vaccine efficacy.

Fc-independent neutralization of SARS-CoV-2 by recombinant human monoclonal antibodies

This study shows that Fc-independent monoclonal antibodies can neutralize SARS-CoV-2 in mice, reducing viral load and preventing mortality without Fc-dependent effector functions.

The neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal antibodies is retained against novel viral variants

This study evaluates the neutralization potency of four SARS-CoV-2 mAbs against spike mutations and two variants of concern, finding that MD65 and BL6 retain effectiveness against B.1.1.7 and B.1.351.

A lipid nanoparticle RBD-hFc mRNA vaccine protects hACE2 transgenic mice against lethal SARS-CoV-2 infection

This study evaluates an mRNA vaccine against SARS-CoV-2 in hACE2 transgenic mice, showing 70% protection against a lethal infection.

Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice

This study identifies and characterizes neutralizing antibodies targeting the SARS-CoV-2 spike N-terminal domain, showing their protective efficacy in mice.

Mice with Induced Pulmonary Comorbidities Display Severe Lung Inflammation and Mortality following Exposure to SARS-CoV-2

This study shows that CD-1 mice with induced pulmonary comorbidities develop severe lung inflammation and high mortality after SARS-CoV-2 infection.

Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody

This study shows that the human monoclonal antibody MD65 can rescue 100% of SARS-CoV-2 infected mice when administered up to 3 days post-exposure.

Development of High-Order Organization of Guanine-Based Reflectors Underlies the Dual Functionality of the Zebrafish Iris

This study investigates the development of a high-order organization of guanine-based reflectors in zebrafish irises, revealing how this structure enables dual functionality as a light barrier and camouflage.