A. Mechaly

CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancy

The paper shows that CREBBP mutations disrupt chromatin loading dynamics and EP300 redundancy, creating zombie enzymes that impair enhancer activation in GC B-cells and lymphoma.

Ton Motor Conformational Switch and Peptidoglycan Role in Bacterial Nutrient Uptake

The paper investigates the conformational switch of ExbD in the Ton system and its role in nutrient uptake, revealing the anchoring function of peptidoglycan and proposing a mechanistic model.

Interactions of the Protein Tyrosine Phosphatase PTPN3 with Viral and Cellular Partners through its PDZ Domain: Insights into Structural Determinants and Phosphatase Activity

This study investigates the interactions of PTPN3's PDZ domain with viral and cellular PBMs, revealing structural determinants and the inhibitory role of the PDZ domain on phosphatase activity.

High resolution cryo-EM and crystallographic snapshots of the large actinobacterial 2-oxoglutarate dehydrogenase: an all-in-one fusion with unique properties

This paper presents high-resolution cryo-EM and crystallographic structures of the actinobacterial 2-oxoglutarate dehydrogenase OdhA, revealing its unique all-in-one architecture and regulatory mechanisms.

Structure and dynamic association of an assembly platform subcomplex of the bacterial type II secretion system

The paper determines the structure of the PulL-PulM heterodimer in the T2SS assembly platform and proposes a model for its dynamic role in pseudopilus polymerization.

Dynamics and structural changes of calmodulin upon interaction with its potent antagonist calmidazolium

This study characterizes the structural and dynamic changes in calmodulin upon binding to calmidazolium, revealing conformational shifts similar to those induced by peptide ligands.

Interactions of SARS-CoV-2 protein E with cell junctions and polarity PDZ-containing proteins

This study investigates how SARS-CoV-2 protein E interacts with PDZ-containing proteins involved in cell junctions and polarity, showing structural and functional differences between variants.

Isolation and characterization of a highly specific monoclonal antibody targeting the botulinum neurotoxin type E exposed SNAP-25 neoepitope

This paper isolates a highly specific monoclonal antibody that detects the BoNT/E-cleaved SNAP-25 neoepitope with ultra-high affinity and no cross-reactivity.

The neutralization potency of anti-SARS-CoV-2 therapeutic human monoclonal antibodies is retained against novel viral variants

This study evaluates the neutralization potency of four SARS-CoV-2 mAbs against spike mutations and two variants of concern, finding that MD65 and BL6 retain effectiveness against B.1.1.7 and B.1.351.

Therapeutic antibodies, targeting the SARS-CoV-2 spike N-terminal domain, protect lethally infected K18-hACE2 mice

This study identifies and characterizes neutralizing antibodies targeting the SARS-CoV-2 spike N-terminal domain, showing their protective efficacy in mice.

Post-exposure protection of SARS-CoV-2 lethal infected K18-hACE2 transgenic mice by neutralizing human monoclonal antibody

This study shows that the human monoclonal antibody MD65 can rescue 100% of SARS-CoV-2 infected mice when administered up to 3 days post-exposure.

A high-affinity calmodulin-binding site in the CyaA toxin translocation domain is essential for invasion into eukaryotic cells

Tiger team: a panel of human neutralizing mAbs targeting SARS-CoV-2 spike at multiple epitopes

This paper isolates and characterizes a panel of human neutralizing monoclonal antibodies targeting SARS-CoV-2 spike at multiple epitopes, suggesting their potential for combined post-exposure therapy.