P. Soon-Shiong

This paper develops a self-amplifying RNA vaccine against SARS-CoV-2 with room-temperature stability and strong immune responses in preclinical studies.

The paper analyzes HLA-I and HLA-II binding peptides in SARS-CoV-2 spike and nucleocapsid proteins across variants to assess T-cell epitope conservation and evasion potential.

This study evaluates heterologous vaccination with two SARS-CoV-2 vaccines in mice, finding enhanced humoral and T-cell responses and broad neutralizing activity against variants.

This study uses mRNA display to identify and engineer neutralizing antibodies against SARS-CoV-2 variants, revealing binding modes and demonstrating their effectiveness against mutations in the spike protein.

This paper introduces a deep learning-based tool for digital pathology annotation that reduces annotation time while maintaining accuracy, validated on CAMELYON16 and TCGA datasets.

This study evaluates a dual-antigen Ad5 vaccine delivered via subcutaneous and intranasal routes in mice, showing that combined prime-only delivery elicits strong humoral and T-cell responses against SARS-CoV-2.

The paper develops an ACE2 Triple Decoy that maintains high affinity for SARS-CoV-2 variants and shows enhanced affinity for specific mutations.

The paper uses molecular dynamics simulations to study SARS-CoV-2 spike RBD interactions with ACE2, revealing an optimized binding conformation and potential targets for therapeutics.

hAd5 spike + nucleocapsid SC prime/oral boost vaccine elicits humoral and T-cell responses and protects rhesus macaques from SARS-CoV-2 challenge.

This paper describes a bivalent hAd5 vaccine combining S-Fusion and N-ETSD antigens that elicits strong Th1-biased T-cell and neutralizing antibody responses in pre-clinical models.

This study shows PD-L1 CAR-engineered NK cells kill cancer cells and inhibit tumor growth by targeting PD-L1, reducing myeloid cells in both preclinical models and patient blood.

The paper identifies a 32-gene immune signature in Treg-enriched tumor samples that correlates with chemosensitivity, overall survival, and immunogenic tumor microenvironment features.