Author

D. Heiser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Fromowitz· 1 shared A. Kulkarni· 1 shared A. Larbi· 1 shared A. M. Nguyen· 1 shared A. Unterreiner· 1 shared A. Verma· 1 shared B. Kamens· 1 shared B. Komalo· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCancer Biology

A. Fromowitz

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activation

M. Venkatasubramanian, L. Schwartz, N. Ramachandra, J. Bennett, K. R. Subramanian, S. Gordon-Mitchell, A. Fromowitz, K. Pradhan, D. Shechter, S. Sahu, D. Heiser, P. Scherle, X. Chen, C. Chetal, A. Kulkarni, , N. G. Salomonis

The paper identifies a splicing mechanism in AML independent of mutations, showing it drives poor prognosis and can be targeted with PRMT5 inhibition.

bioRxiv · Feb 4, 2024Cancer Biology

Evaluation of protein kinase D auto-phosphorylation as biomarker for NLRP3 inflammasome activation

D. Heiser, J. Rubert, A. Unterreiner, C. Maurer, M. Kamke, U. Bodendorf, C. J. Farady, B. Roediger, F. Bornancin

This study evaluates PKD auto-phosphorylation as a biomarker for NLRP3 inflammasome activation, finding it precedes inflammasome activity but is also triggered by non-NLRP3 stimuli.

bioRxiv · Mar 4, 2021Cell Biology

A Multi-Phenotype System to Discover Therapies for Age-Related Dysregulation of the Immune Response to Viral Infections

B. W. White, B. Komalo, L. Nicolaisen, M. Donne, C. Marsh, R. M. DeVay, A. M. Nguyen, W. Cousin, J. Heinrich, W. J. Van Trump, T. Plott, C. J. Fuller, D. Nguyen, D. Chen, D. Bucher, , B. Kamens

This paper develops a multi-phenotype system to identify compounds that rejuvenate the immune response in older adults to viral infections, finding disulfiram and triptonide as promising candidates.

bioRxiv · Jul 30, 2020 · PreprintImmunology