Author

D. Hellerschmied

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Organism:human· 2 Assay:protein structure· 2 Approach:biophysical modeling· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

F. Kaschani· 3 shared M. Kaiser· 3 shared A. M. Winkelkotte· 1 shared A. Tannapfel· 1 shared A. Walch· 1 shared C. Beuck· 1 shared C. Muench· 1 shared D. L. Paterson· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersBiochemistry

F. Kaschani

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Induced degradation of SNAP-fusion proteins

S. Abraham Pol, S. Liljenberg, J. Barr, G. Simon, L. Wong-Dilworth, D. L. Paterson, V. P. Berishvili, F. Bottanelli, F. Kaschani, M. Kaiser, M. Pettersson, D. Hellerschmied

This paper develops SNAP-PROTACs to induce degradation of SNAP-fusion proteins, enabling selective depletion and functional analysis of target proteins.

bioRxiv · Jul 18, 2024Cell Biology

Conformational plasticity of a BiP-GRP94 chaperone complex

J. C. Brenner, L. C. Zirden, Y. Almeida-Hernandez, F. Kaschani, M. Kaiser, E. Sanchez-Garcia, S. Poepsel, D. Hellerschmied

This study characterizes the conformational changes of the BiP-GRP94 chaperone complex and identifies the structural basis of their interaction without co-chaperones.

bioRxiv · Feb 1, 2024Biochemistry

High resolution analysis of proteolytic substrate processing

J. Schillinger, M. Koci, K. Bravo Rodriguez, G. Heilmann, F. Kaschani, M. Kaiser, C. Beuck, H. Luecke, R. Huber, D. Hellerschmied, S. G. Burston, M. Ehrmann

The paper develops an integrated method to analyze proteolytic substrate processing at high resolution using time-resolved mass spectrometry and other techniques.

bioRxiv · Mar 24, 2022Biochemistry

Functional metabolic phenotyping of human pancreatic ductal adenocarcinoma

I. Heid, S. Karakaya, C. Muench, S. S. Lueong, A. M. Winkelkotte, S. T. Liffers, L. Godfrey, P. F. Cheung, K. Savvatakis, G. J. Topping, F. Englert, L. Kritzner, M. Grashei, T. Kunzke, N. Sun, , J. T. Siveke

This study identifies functional metabolic differences between PDAC subtypes and shows that non-invasive HP-MRS can detect glycolytic tumor metabolism.

bioRxiv · Jul 23, 2021 · PreprintCancer Biology