F. Kaschani

α-Aminooxyacetic acid derivatives acting as pro-drugs against Mycobacterium tuberculosis

This study identifies novel anti-TB pro-drugs based on α-aminooxyacetic acid that are effective against M. tuberculosis and show low cytotoxicity.

Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression in planta.

The paper identifies active cytochrome P450s in mouse, plant, and fungal systems using chemical probes and mass spectrometry, showing their subcellular localization and activity-based labeling.

Glycerol degradation in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius involves an unusual glycerol-3-phosphate dehydrogenase

This study identifies an unusual glycerol-3-phosphate dehydrogenase in Sulfolobus acidocaldarius involved in glycerol degradation, showing its essential role in growth on glycerol.

Conformational plasticity of a BiP-GRP94 chaperone complex

This study characterizes the conformational changes of the BiP-GRP94 chaperone complex and identifies the structural basis of their interaction without co-chaperones.

The proteome of agroinfiltrated Nicotiana benthamiana is shaped by extensive protein processing

The paper identifies extensive proteolytic processing of plant proteins in agroinfiltrated N. benthamiana using peptographs and mass spectrometry, revealing widespread proteoform modifications.

Ipl1-controlled attachment maturation regulates Mps1 association with its kinetochore receptor

The paper shows that Ipl1/Aurora B kinase regulates Mps1's release from kinetochores by competing with Dam1 for binding to Ndc80:Nuf2, enabling proper chromosome segregation.

The anti-tubercular callyaerins target the Mycobacterium tuberculosis-specific non-essential membrane protein Rv2113

This study identifies callyaerins as antitubercular agents targeting the M. tuberculosis-specific protein Rv2113, showing efficacy against drug-resistant strains with minimal cytotoxicity.

Glutathione transferase photoaffinity labeling demonstrates GST activation by safeners and NPR1-independent activation by BTH

The paper introduces a photoaffinity labeling assay to study GST activation in plants, showing safener-induced activation in wheat and BTH-induced activation in Arabidopsis independent of NPR1.

Activity-based proteomics uncovers suppressed hydrolases and a neo-functionalised antibacterial enzyme at the plant-pathogen interface

The paper uses activity-based proteomics to analyze hydrolase activity in plant leaves infected with Pseudomonas syringae, identifying suppressed and activated enzymes and a neo-functionalised antibacterial enzyme.

Factors governing attachment of Rhizobium leguminosarum to legume roots

This study identifies 115 proteins required for Rhizobium leguminosarum attachment to pea roots under varying pH conditions, revealing complex mechanisms and no single essential protein for alkaline attachment.

Environmental activity-based protein profiling for function-driven enzyme discovery from natural communities

This paper introduces eABPP, a proteomics-based method to identify active enzymes in microbial communities, and demonstrates its application in discovering thermostable serine hydrolases from hot springs.

Persister state-directed transitioning and vulnerability in melanoma

This study identifies a compound that induces a persister state in melanoma cells, promoting differentiation and sensitizing them to a prodrug, offering a dual-target strategy for treatment.

High resolution analysis of proteolytic substrate processing

The paper develops an integrated method to analyze proteolytic substrate processing at high resolution using time-resolved mass spectrometry and other techniques.

Homology-guided re-annotation improves the gene models of the alloploid Nicotiana benthamiana

The paper improves gene models of Nicotiana benthamiana using homology-guided re-annotation, resulting in a more complete and accurate proteome database.