Author

G. Simon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Paleontology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. Cravatt· 2 shared J. Teijaro· 2 shared M. Dix· 2 shared M. Lazear· 2 shared Y. Wang· 2 shared A. A. Vashisht· 1 shared A. Prunet· 1 shared A. Saghatelian· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiochemistry

B. Cravatt

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Induced degradation of SNAP-fusion proteins

S. Abraham Pol, S. Liljenberg, J. Barr, G. Simon, L. Wong-Dilworth, D. L. Paterson, V. P. Berishvili, F. Bottanelli, F. Kaschani, M. Kaiser, M. Pettersson, D. Hellerschmied

This paper develops SNAP-PROTACs to induce degradation of SNAP-fusion proteins, enabling selective depletion and functional analysis of target proteins.

bioRxiv · Jul 18, 2024Cell Biology

Micro- to nano-scale investigation of Precambrian metasediments: biogenicity and preservation in the 3.22 Ga Moodies Group (Barberton Greenstone Belt, S. Africa) and the 2.46 Ga Brockman Iron Formation (Hamersley Basin, W. Australia).

H. Bellon, J. Gieraltowski, F. Michaud, G. Simon, S. Cerantola, M. Homann, I. Foster, P. Ballet, S. V. Lalonde

This study uses micro- to nano-scale techniques to analyze filamentous structures in ancient rocks to assess their biogenicity and preservation.

bioRxiv · Feb 8, 2023 · PreprintPaleontology

Proteomic discovery of chemical probes that perturb protein complexes in human cells

M. Lazear, J. Remsberg, M. Jaeger, K. Rothamel, H.-l. Her, K. DeMeester, E. Njomen, S. Hogg, J. Rahman, L. Whitby, S. J. Won, M. Schafroth, D. Ogasawara, M. Yokoyama, G. Lindsey, , B. Cravatt

This study develops a proteomic strategy to identify chemical probes that perturb protein complexes in human cells by analyzing electrophilic compounds' effects on protein interactions.

bioRxiv · Dec 12, 2022Biochemistry

The metabolite alpha-ketobutyrate increases health and life spans by activating AMPK

C. Chen, B. Lomenick, M. Chai, W. Huang, J. Chu, L. Vergnes, R. O. Johnson, A. A. Vashisht, R. M. Chin, M. M. Dix, G. Simon, X. Fu, J. C. Link, H. Hwang, X. Yin, , J. Huang

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

bioRxiv · Oct 10, 2022 · PreprintPhysiology

Development of a soft cell confiner to decipher the impact of mechanical stimuli on cells

A. Prunet, S. Lefort, H. Delanoe-Ayari, S. Saci, G. Simon, F. Argoul, B. Guyot, J.-P. Rieu, S. Gobert, V. Maguer-Satta, C. Riviere

The paper develops a soft cell confiner to study the long-term effects of mechanical confinement on cell biology, finding that viability remains unaffected but proliferation decreases.

bioRxiv · Jan 4, 2020Biophysics

An activity-guided map of electrophile-cysteine interactions in primary human immune cells

E. Vinogradova, D. Lazar, R. Suciu, Y. Wang, G. Bianco, Y. Yamashita, V. Crowley, D. Remillard, K. Lum, G. Simon, E. Kemper, M. Lazear, S. Yin, M. Blewett, M. Dix, , B. Cravatt

The paper maps electrophile-sensitive cysteines in primary human T cells and shows how electrophilic compounds affect T cell activation through cysteine modification.

bioRxiv · Oct 17, 2019 · PreprintImmunology

Simultaneous tracking of division and differentiation from individual hematopoietic stem and progenitor cells reveals within-family homogeneity despite population heterogeneity

T. Tak, G. Prevedelllo, G. Simon, N. Paillon, K. R. Duffy, L. Perie

This study tracks division and differentiation of hematopoietic stem and progenitor cells to show that cells from the same ancestor are homogeneous despite population-level heterogeneity.

bioRxiv · Mar 26, 2019 · PreprintImmunology