M. Kaiser

Induced degradation of SNAP-fusion proteins

This paper develops SNAP-PROTACs to induce degradation of SNAP-fusion proteins, enabling selective depletion and functional analysis of target proteins.

Local genetic adaptation to habitat in wild chimpanzees

This study identifies local genetic adaptation to habitat in wild chimpanzees, particularly to pathogens like malaria, using newly generated exomes.

De novo synthesis of fatty acids in Archaea via an archaeal fatty acid synthase complex

This study shows that archaea can synthesize fatty acids using a newly identified pathway and enzyme complex, providing insights into their evolutionary lipid composition.

Extracellular plant subtilases dampen cold shock peptide elicitor levels

The paper shows that the plant subtilase SBT5.2a cleaves the bacterial cold-shock protein csp22, reducing its immunogenicity and pathogen growth.

Subtilase SBT5.2 inactivates flagellin immunogenicity in the plant apoplast

The paper shows that the subtilase SBT5.2 cleaves flagellin's flg22 epitope, inactivating its immunogenicity and controlling immune responses in plants.

α-Aminooxyacetic acid derivatives acting as pro-drugs against Mycobacterium tuberculosis

This study identifies novel anti-TB pro-drugs based on α-aminooxyacetic acid that are effective against M. tuberculosis and show low cytotoxicity.

Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression in planta.

The paper identifies active cytochrome P450s in mouse, plant, and fungal systems using chemical probes and mass spectrometry, showing their subcellular localization and activity-based labeling.

Glycerol degradation in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius involves an unusual glycerol-3-phosphate dehydrogenase

This study identifies an unusual glycerol-3-phosphate dehydrogenase in Sulfolobus acidocaldarius involved in glycerol degradation, showing its essential role in growth on glycerol.

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity.

This paper identifies molecular glues that stabilize the ChREBP/14-3-3 complex, protecting beta cells from glucolipotoxicity by preventing ChREBP-mediated dedifferentiation.

Conformational plasticity of a BiP-GRP94 chaperone complex

This study characterizes the conformational changes of the BiP-GRP94 chaperone complex and identifies the structural basis of their interaction without co-chaperones.

Venturicidin A affects the mitochondrial membrane potential and induces kDNA loss in Trypanosoma brucei

This study shows venturicidin A targets ATP synthase in Trypanosoma brucei, causing mitochondrial membrane potential loss and kDNA loss, suggesting it as a potential antitrypanosomatid drug.

The proteome of agroinfiltrated Nicotiana benthamiana is shaped by extensive protein processing

The paper identifies extensive proteolytic processing of plant proteins in agroinfiltrated N. benthamiana using peptographs and mass spectrometry, revealing widespread proteoform modifications.

Induced pluripotent stem cell-derived human macrophages as an infection model for Leishmania donovani

This paper uses human induced pluripotent stem cell-derived macrophages to model Leishmania donovani infection and test drug efficacy, showing comparable results to mouse macrophages.

The anti-tubercular callyaerins target the Mycobacterium tuberculosis-specific non-essential membrane protein Rv2113

This study identifies callyaerins as antitubercular agents targeting the M. tuberculosis-specific protein Rv2113, showing efficacy against drug-resistant strains with minimal cytotoxicity.

Enhanced late blight resistance by engineering an EpiC2B-insensitive immune protease

The paper enhances late blight resistance in tomato by engineering an immune protease insensitive to a pathogen inhibitor.

Glutathione transferase photoaffinity labeling demonstrates GST activation by safeners and NPR1-independent activation by BTH

The paper introduces a photoaffinity labeling assay to study GST activation in plants, showing safener-induced activation in wheat and BTH-induced activation in Arabidopsis independent of NPR1.

Activity-based proteomics uncovers suppressed hydrolases and a neo-functionalised antibacterial enzyme at the plant-pathogen interface

The paper uses activity-based proteomics to analyze hydrolase activity in plant leaves infected with Pseudomonas syringae, identifying suppressed and activated enzymes and a neo-functionalised antibacterial enzyme.

Factors governing attachment of Rhizobium leguminosarum to legume roots

This study identifies 115 proteins required for Rhizobium leguminosarum attachment to pea roots under varying pH conditions, revealing complex mechanisms and no single essential protein for alkaline attachment.

Environmental activity-based protein profiling for function-driven enzyme discovery from natural communities

This paper introduces eABPP, a proteomics-based method to identify active enzymes in microbial communities, and demonstrates its application in discovering thermostable serine hydrolases from hot springs.

High resolution analysis of proteolytic substrate processing

The paper develops an integrated method to analyze proteolytic substrate processing at high resolution using time-resolved mass spectrometry and other techniques.

BacPROTACs mediate targeted protein degradation in bacteria

This paper develops BacPROTACs, small-molecule degraders that target bacterial proteins by activating the ClpC:ClpP protease, demonstrating in vivo degradation in mycobacteria.

Persister state-directed transitioning and vulnerability in melanoma

This study identifies a compound that induces a persister state in melanoma cells, promoting differentiation and sensitizing them to a prodrug, offering a dual-target strategy for treatment.

Non-invasive monitoring of drug action: a new live in vitro assay design for Chagas' disease drug discovery

This paper introduces a live in vitro assay using eGFP-expressing Trypanosoma cruzi to monitor drug action over 6 days, revealing pharmacodynamic profiles of benznidazole and posaconazole.

NIHBA: A Network Interdiction Approach with Hybrid Benders Algorithm for Strain Design

This paper introduces a hybrid Benders algorithm for strain design using a network interdiction model, achieving efficient and scalable solutions for metabolic network redesign.

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

This study identifies CLK1 as a novel drug target in Trypanosoma brucei by showing its essential role in kinetochore function and cell survival through kinase inhibition.

Homology-guided re-annotation improves the gene models of the alloploid Nicotiana benthamiana

The paper improves gene models of Nicotiana benthamiana using homology-guided re-annotation, resulting in a more complete and accurate proteome database.