M. Ahmad

Vaginal lactobacilli produce anti-inflammatory beta-carboline compounds.

This study identifies beta-carboline compounds produced by vaginal lactobacilli that reduce inflammation by suppressing immune signaling pathways and demonstrate therapeutic potential in a mouse model.

The origin, deployment, and evolution of a plant-parasitic nematode effectorome

This study identifies and characterizes the effectorome of the plant-parasitic nematode Heterodera schachtii, revealing 659 effector gene loci and providing insights into their origin, deployment, and evolution.

Chemical inhibition of histidine biosynthesis curtails M. tuberculosis infection

This study designs triazole inhibitors targeting M. tuberculosis's histidine biosynthesis pathway, showing efficacy against drug-resistant strains and reducing bacterial burden in infected mice.

O-GlcNAcylation promotes YTHDF1 cytosolic localization and colorectal cancer tumorigenesis

This study shows O-GlcNAcylation of YTHDF1 enhances its cytosolic localization and promotes colorectal cancer by increasing c-Myc expression.

A Generalizable Nanopore Sensor for Highly Specific Protein Detection at Single-Molecule Precision

This paper introduces a nanopore sensor for specific protein detection without steric hindrance, validated across diverse proteins with unique electrical signatures.

The role of floral traits in community assembly process at high elevations in Lesser Himalaya

This study examines how floral traits influence plant community assembly along an elevation gradient in the Lesser Himalaya, finding that abiotic factors and pollinator interactions shape floral trait composition.

Functional Communication between IP3R and STIM2 at sub-threshold stimuli is a critical checkpoint for initiation of SOCE

This study identifies IP3R-mediated local [Ca2+]ER decreases as the driver of immobile STIM2 clusters at ER-PM junctions, marking a checkpoint for SOCE initiation under sub-threshold stimuli.

Molecular basis of the logical evolution of the novel coronavirus SARS-CoV-2: A comparative analysis

This study compares the SARS-CoV-2 spike protein structure with other coronaviruses to identify amino acid changes responsible for increased infectivity and conformational flexibility.

B1 and B2 B cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers

The paper identifies distinct CpG modification states in B1 and B2 B cells at DNMT3A-maintained enhancers, showing differential methylation dynamics during development.

Potential short-term negative versus positive effects of olive mill-derived biochar on nutrient availability in a calcareous loamy sandy soil

This study evaluates the effects of olive mill-derived biochar on soil nutrient availability and maize growth, finding increased K, Na, and Zn availability but reduced P, Ca, Mg, and Mn in shoots.

Extreme acid resistance of human cheek epithelial cells.

This study investigates the acid resistance of human cheek epithelial cells, finding they survive in highly acidic conditions without bursting and show no gender-based differences in resistance.

Relative Principal Components Analysis: Application to Analyzing Biomolecular Conformational Changes

This paper introduces RPCA to analyze conformational changes in HIV-1 protease upon drug binding, showing it provides a thermodynamic framework for understanding structural dynamics.

Dynamic Kinetochore Size Regulation Promotes Microtubule Capture And Chromosome Biorientation In Mitosis

The paper shows that Spindly-based dynamic regulation of kinetochore size ensures proper microtubule capture and chromosome segregation by controlling corona expansion and shedding.