Author

H. Ovaa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Organism:bacteria (other)· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

P. P. Geurink· 5 shared A. Sapmaz· 2 shared D. Komander· 2 shared J. Gan· 2 shared A. Aimon· 1 shared A. Bradley· 1 shared A. Douangamath· 1 shared A. E. Au· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersBiochemistry

P. P. Geurink

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

USP16 is an ISG15 cross-reactive deubiquitinase targeting a subset of metabolic pathway-related proteins

J. Gan, A. Pinto-Fernandez, D. Flierman, J. J. L. L. Akkermans, D. P. O'Brien, H. Greenwood, H. C. Scott, J. Neefjes, G. Fritz, K.-P. Knobeloch, H. van Dam, B. M. Kessler, H. Ovaa, P. P. Geurink, A. Sapmaz

This study identifies USP16 as an ISG15 cross-reactive deubiquitinase that regulates metabolic pathway-related proteins during type I interferon responses.

bioRxiv · Jun 26, 2023 · PreprintBiochemistry

Allosteric control of Ubp6 and the proteasome via a bidirectional switch

K. Y. S. Hung, S. Klumpe, M. R. Eisele, S. Elsasser, G. Tian, S. Sun, J. A. Moroco, T. C. Cheng, T. Joshi, T. Seibel, D. Van Dalen, X.-H. Feng, Y. Lu, H. Ovaa, J. R. Engen, , D. Finley

This study identifies an allosteric switch that controls Ubp6 and the proteasome, showing their active states are mutually exclusive.

bioRxiv · Jul 16, 2021Biochemistry

Signal Inhibitory Receptor on Leukocytes-1 recognizes S100 proteins

M. Rumpret, H. J. von Richthofen, M. van der Linden, G. H. A. Westerlaken, C. Talavera Ormeno, T. Y. Low, H. Ovaa, L. Meyaard

This study identifies S100 proteins as ligands for the inhibitory receptor SIRL-1, showing that SIRL-1 suppresses neutrophil ROS production via binding to S100A6.

bioRxiv · May 14, 2021Immunology

Mechanism and inhibition of SARS-CoV-2 PLpro

T. Klemm, G. Ebert, D. J. Calleja, C. C. Allison, L. W. Richardson, J. P. Bernardini, B. G. C. Lu, N. W. Kuchel, C. Grohmann, Y. Shibata, Z. Y. Gan, J. P. Cooney, M. Doerflinger, A. E. Au, T. R. Blackmore, , D. Komander

This study investigates SARS-CoV-2 PLpro's mechanism and identifies non-covalent inhibitors with antiviral activity.

bioRxiv · Jun 18, 2020Biochemistry

Identification and characterization of diverse OTU deubiquitinases in bacteria

A. F. Schubert, J. V. Nguyen, T. G. Franklin, P. P. Geurink, C. G. Roberts, D. J. Sanderson, L. N. Miller, H. Ovaa, K. Hofmann, J. N. Pruneda, D. Komander

The paper identifies and characterizes OTU deubiquitinases in bacteria, showing their structural and functional similarities to human and viral OTUs.

bioRxiv · Mar 28, 2020Biochemistry

A Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

P. P. Geurink, R. Kooij, A. Sapmaz, S. Liu, B.-T. Xin, G. M. C. Janssen, P. A. van Veelen, P. ten Dijke, H. Ovaa

This paper develops a fluorescent small-molecule probe to monitor UCHL1 activity in live cells and zebrafish embryos, showing specificity for UCHL1 over other DUBs.

bioRxiv · Nov 1, 2019Biochemistry

Discovery and Optimization of Inhibitors for the Pup Proteasome System in Mycobacterium tuberculosis

G. Janssen, R. Merkx, S. Zhang, C. Schiesswohl, C. Chatterjee, H. Darwin, H. Ovaa

This study identifies and optimizes inhibitors of the Pup proteasome system in M. tuberculosis through high-throughput screening and SAR analysis.

bioRxiv · Oct 7, 2019 · PreprintMicrobiology

Rapid covalent-probe discovery by electrophile fragment screening

e. resnick, A. Bradley, J. Gan, A. Douangamath, T. Krojer, R. Sethi, A. Aimon, G. Amitai, D. Belini, J. Bennett, M. Fairhead, O. Fedorov, P. P. Geurink, J. Guo, A. Plotnikov, , N. London

This study develops a method for discovering covalent probes using electrophile fragment screening and identifies selective inhibitors for OTUB2 and NUDT7.

bioRxiv · Oct 14, 2018Biochemistry