Author

D. Kan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Ashkenazi· 2 shared E. Segal· 2 shared J. Rudolph· 2 shared K. Clark· 2 shared M. Beresini· 2 shared M.-G. Braun· 2 shared W. Sandoval· 2 shared A. Gogineni· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

A. Ashkenazi

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2 papers

Recent·Most cited

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth

I. Zuazo-Gaztelu, D. Lawrence, I. Oikonomidi, S. Marsters, X. Pechuan-Jorge, C. J. Gaspar, D. Kan, E. Segal, K. Clark, M. Beresini, M.-G. Braun, J. Rudolph, Z. Modrusan, M. Choi, W. Sandoval, , A. Ashkenazi

This study identifies a nonenzymatic role of IRE1 in cancer cell cycle progression and tumor growth, independent of its kinase-RNase activity.

bioRxiv · Nov 22, 2023Cancer Biology

Disruption of IRE1α through its Kinase Domain Attenuates Multiple Myeloma

J. M. Harnoss, A. Le Thomas, S. A. Marsters, D. A. Lawrence, M. Lu, Y.-C. A. Chen, J. Qing, K. Totpal, D. Kan, E. Segal, H. Ackerly Wallweber, W. Wang, K. Clark, S. Kaufman, M. Beresini, , A. Ashkenazi

This study shows that disrupting IRE1α's kinase domain reduces multiple myeloma tumor growth and enhances treatment efficacy, suggesting it as a therapeutic target.

bioRxiv · Dec 14, 2018 · PreprintCancer Biology