M. Choi

Selective enrichment of Methylococcaceae versus Methylocystaceae methanotrophs via control of methane feeding scheme

This study enriches methanotrophic microbiomes from paddy soils under different methane and copper conditions, finding Methylocystis dominance and ecological importance of methanobactin in Cu-deficient environments.

A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth

This study identifies a nonenzymatic role of IRE1 in cancer cell cycle progression and tumor growth, independent of its kinase-RNase activity.

Increasing the Throughput and Reproducibility of Activity-Based Proteome Profiling Studies with Hyperplexing and Intelligent Data Acquisition

The paper introduces InSeqAPI and PairQuant to enhance ABPP throughput and reproducibility using hyperplexing and IDA, identifying new druggable sites in nuclear proteins.

Conserved long noncoding RNA TILAM promotes liver fibrosis through interaction with PML in hepatic stellate cells

This study identifies TILAM, a conserved lncRNA that promotes liver fibrosis by interacting with PML in HSCs, and shows its depletion reduces fibrosis in mouse models.

Structural insights into ubiquitin chain cleavage by Legionella ovarian tumor deubiquitinases

This study reveals the structural features and mechanism of Legionella OTU deubiquitinases, showing their unique extended helical lobe and cooperative chain cleavage activity.

Surface-based Characterization of Gastric Anatomy and Motility using Magnetic Resonance Imaging and Neural Ordinary Differential Equation

This paper introduces a method using MRI and neural ODEs to model gastric motility and anatomy in rats, revealing functional regions and muscle activity patterns.

Quantifying microbial associations of dissolved organic matter under global change

The paper develops a framework to quantify DOM-microbe associations under global change, finding that molecular traits and nutrient enrichment influence these interactions differently in subarctic and subtropical climates.

Optical topometry and machine learning to rapidly phenotype stomatal patterning traits for QTL mapping in maize

Optical topometry and machine learning tools were developed to assess epidermal cell patterning, and applied to analyze its genetic architecture alongside leaf photosynthetic gas exchange in maize.

Proteomics of autophagy deficient macrophages reveals enhanced antimicrobial immunity via the oxidative stress response

This study shows that loss of Atg16l1 in macrophages enhances antimicrobial immunity against Shigella flexneri via the oxidative stress response.

MitoROS due to loss of Slc4a11 in corneal endothelial cells induces ER stress, lysosomal dysfunction and impairs autophagy

This study shows that loss of Slc4a11 in corneal endothelial cells leads to mitochondrial ROS, which causes ER stress, lysosomal dysfunction, and impaired autophagy.

Machine learning reveals heterogeneous responses to FAK, Rac, Rho, and Cdc42 inhibition on vascular smooth muscle cell spheroid formation and morphology

This study uses HETEROID to analyze how FAK, Rac, Rho, and Cdc42 inhibitors affect VSMC spheroid formation and morphology, revealing pathway-specific responses.