Chemical inhibition of histidine biosynthesis curtails M. tuberculosis infection
S. Tiwari, M. Ahmad, V. Kumar, D. Kar, S. Kumari, A. Dwivedy, R. K. Pal, A. K. MOHAPATRA, V. K. Nain, V. Barik, R. Pal, R. K. Nanda, A. K. Pandey, B. Biswal
This study designs triazole inhibitors targeting M. tuberculosis's histidine biosynthesis pathway, showing efficacy against drug-resistant strains and reducing bacterial burden in infected mice.
bioRxiv · Jun 20, 2023 · PreprintBiochemistry