Type I Interferon Limits Viral Dissemination-Driven Clinical Heterogeneity in a Native Murine Betacoronavirus Model of COVID-19
H. Qing, L. Sharma, B. K. Hilliard, X. Peng, A. Swaminathan, J. Tian, K. Israni-Winger, C. Zhang, D. Leao, S. Ryu, V. Habet, L. Wang, X. Tian, S. Ishibe, L. H. Young, , A. Wang
This study establishes a murine model of COVID-19 using MHV-A59 and shows that type-I interferons limit viral dissemination, reducing lethality and recapitulating key clinical features.
bioRxiv · Sep 11, 2020 · PreprintImmunology