S. Ryu

Sulfasalazine promotes myogenic differentiation via increasing of fast myosin heavy chain isoforms

This study shows sulfasalazine promotes myogenic differentiation by increasing fast myosin heavy chain isoforms through a metabolic shift to glycolysis in C2C12 myoblasts and improves muscle function in aged and injured mice.

The fingering patterns in the epithelial layer control the gap closure rate via curvature-mediated force

The paper shows that fingering patterns in epithelial layers influence gap closure speed through curvature-mediated forces, with fingering frequency inversely related to boundary curvature.

Phylogenetic Association and Genetic Factors in Cold Stress Tolerance in Campylobacter jejuni

This study identifies phylogenetic clusters and the gene cfrA as factors contributing to cold stress tolerance in Campylobacter jejuni.

Development of fluoroquinolone resistance through antibiotic tolerance in Campylobacter jejuni

This study shows that antibiotic tolerance in Campylobacter jejuni induced by ciprofloxacin and tetracycline leads to rapid development of fluoroquinolone resistance.

Salmonella Typhimurium uses anaerobic respiration to overcome propionate-mediated colonization resistance

This study shows Salmonella Typhimurium uses propionate as a carbon source for anaerobic respiration to overcome colonization resistance in the gut.

Type I Interferon Limits Viral Dissemination-Driven Clinical Heterogeneity in a Native Murine Betacoronavirus Model of COVID-19

This study establishes a murine model of COVID-19 using MHV-A59 and shows that type-I interferons limit viral dissemination, reducing lethality and recapitulating key clinical features.

Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model

This study shows that a ketogenic diet reduces inflammation and improves outcomes in aged mice infected with a coronavirus, suggesting potential therapeutic benefits for elderly COVID-19 patients.

ADAR1 editing dependency in triple-negative breast cancer

This study shows ADAR1 is essential for TNBC cell proliferation and tumorigenesis, with its loss reducing proliferation and being rescued by IFNAR1 reduction.

A Versatile Polypharmacology Platform Promotes Cytoprotection and Viability of Human Pluripotent and Differentiated Cells

The paper identifies a small molecule cocktail, CEPT, that enhances the viability and cytoprotection of human pluripotent and differentiated cells through multi-target drug combinations.

Understanding and eliminating the detrimental effect of endogenous thiamine auxotrophy on metabolism of the oleaginous yeast Yarrowia lipolytica

This study identifies the genetic basis of thiamine auxotrophy in Yarrowia lipolytica and engineers a thiamine-prototrophic strain with enhanced lipid production.

Active behaviour during early development shapes glucocorticoid reactivity

The paper shows that early developmental swimming in zebrafish alters cortisol stress responses and related behaviors.

Exceptional Solvent Tolerance in Yarrowia lipolytica Is Enhanced by Sterols

This study engineered Yarrowia lipolytica to tolerate high concentrations of ionic liquids by enhancing sterol content in cell membranes, enabling robust growth in up to 18% [EMIM][OAc].

Understanding Functional Roles of Native Pentose-Specific Transporters for Activating Dormant Pentose Metabolism in Yarrowia lipolytica

This study identifies native pentose-specific transporters in Yarrowia lipolytica that enhance xylose and arabinose assimilation, revealing a dormant pentose metabolism pathway.