Author

D. Legouis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Faivre· 2 shared A. P. McMahon· 2 shared J. Pugin· 2 shared K. Koppitch· 2 shared M. Naesens· 2 shared P. Galichon· 2 shared S. de Seigneux· 2 shared A. Hertig· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersPathology

A. Faivre

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single-cell profiling in COVID-19 associated acute kidney injury reveals patterns of tubule injury and repair in human

D. Legouis, A. Rinaldi, G. Arnoux, T. Verissimo, J. Scotti-Gerber, A. Faivre, M. Schibler, A. Rinaldi, M. Naesens, K. Koppitch, J. Pugin, A. P. McMahon, S. Moll, S. de Seigneux, P. E. Cippa

This study uses single-nucleus RNA sequencing to analyze kidney tubule injury and repair in COVID-19 patients, identifying cell state transitions and reparative mechanisms.

bioRxiv · Oct 5, 2021Pathology

Proliferation impairs cell viability via energy depletion

P. Galichon, M. Lannoy, L. Li, S. Vandermeersch, D. Legouis, M. T. Valerius, J. Hadchouel, J. V. Bonventre

The paper shows that proliferation in kidney cells reduces energy availability, leading to cell death and chronic kidney disease under metabolic stress.

bioRxiv · Apr 24, 2020 · PreprintPhysiology

Impaired renal gluconeogenesis is a major determinant of acute kidney injury associated mortality

D. Legouis, S.-E. Ricksten, A. Faivre, K. Gariani, P. Galichon, L. Berchtold, E. Feraille, K. Koppitch, A. Hertig, P.-Y. Martin, M. Naesens, J. Pugin, A. P. McMahon, P. E. Cippà, S. de Seigneux

This study shows impaired renal gluconeogenesis during AKI contributes to systemic metabolic disturbances and mortality, with thiamine supplementation reducing mortality in critically ill patients.

bioRxiv · Oct 16, 2019Cell Biology