Cancer BiologybioRxivPreprint
Loss-of-SIRT7 sensitizes hepatocellular carcinoma to sorafenib through the regulation of ERK Phosphorylation
Y. Kim, K.-Y. Jung, Y. H. Kim…·J. Auwerx
This study shows that SIRT7 contributes to sorafenib resistance in HCC by enhancing ERK phosphorylation, and inhibiting SIRT7 with sorafenib reduces tumor growth.
DOI 10.1101/2023.03.13.531998