Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles
Z. Mu, K. Wiehe, K. O. Saunders, R. Henderson, D. W. Cain, R. Parks, D. Martik, K. Mansouri, R. J. Edwards, A. Newman, X. Lu, S.-M. Xia, M. Bonsignori, D. Montefiori, Q. Han, , B. F. Haynes
This study shows that nucleoside-modified mRNA can encode HIV-1 Env trimer nanoparticles that induce bnAb precursor B cell expansion and neutralizing activity in mice.
bioRxiv · Aug 9, 2021 · PreprintImmunology