M. Bonsignori

Mutation-Guided Vaccine Design: A Strategy for Developing Boosting Immunogens for HIV Broadly Neutralizing Antibody Induction

The paper demonstrates a mutation-guided vaccine strategy that induces HIV broadly neutralizing antibodies in mice by selecting for rare B cell lineage mutations.

Zika virus-specific IgM elicited during pregnancy exhibits ultrapotent neutralization

This study identifies a potent ZIKV-neutralizing IgM antibody from a pregnant woman and shows its protective efficacy in mice.

Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles

This study shows that nucleoside-modified mRNA can encode HIV-1 Env trimer nanoparticles that induce bnAb precursor B cell expansion and neutralizing activity in mice.

Rapid selection of HIV envelopes that bind to neutralizing antibody B cell lineage members with functional improbable mutations

The paper identifies a minimal set of mutations required for the function of a HIV bnAb and demonstrates in vitro selection of envelope immunogens that can bind to antibodies with these mutations.

Recapitulation of HIV-1 Env-Antibody Coevolution in Macaques Leading to Neutralization Breadth

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.

Fab-dimerized glycan-reactive antibodies neutralize HIV and are prevalent in humans and rhesus macaques

The paper identifies Fab-dimerized glycan-reactive antibodies in HIV-infected macaques and HIV-naïve humans that neutralize HIV-1 and can be elicited by vaccination.

Antibody feedback limits the expansion of cognate memory B cells but drives the diversification of vaccine-induced antibody responses

The paper shows antibody feedback limits memory B cell expansion but allows diversification of vaccine-induced antibody responses by suppressing dominant epitopes while enabling subdominant ones.

Functional Improbable Antibody Mutations Critical for HIV Broadly Neutralizing Antibody Development

The paper identifies improbable mutations critical for HIV broadly neutralizing antibody development and proposes a mutation-guided vaccine strategy.