Mutation-Guided Vaccine Design: A Strategy for Developing Boosting Immunogens for HIV Broadly Neutralizing Antibody Induction
K. Wiehe, K. O. Saunders, V. Stalls, D. W. Cain, S. Venkatayogi, J. S. Martin Beem, M. Berry, T. Evangelous, R. Henderson, B. Hora, S.-M. Xia, C. Jiang, A. Newman, C. Bowman, X. Lu, , B. F. Haynes
The paper demonstrates a mutation-guided vaccine strategy that induces HIV broadly neutralizing antibodies in mice by selecting for rare B cell lineage mutations.
bioRxiv · Nov 11, 2022 · PreprintImmunology