A. Newman

Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

Non-stabilized SARS-CoV-2 Spike mRNA vaccination in macaques induces B cell lineages targeting conserved epitopes on Omicron variants or cross-neutralizing epitopes on Sarbecoviruses.

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.

Vaccine-mediated protection against merbecovirus and sarbecovirus challenge in mice

This study develops a trivalent RBD nanoparticle vaccine that protects mice against both merbecovirus and sarbecovirus challenges, including SARS-CoV, MERS-CoV, and SARS-CoV-2.

Engineered Immunogens to Elicit Antibodies Against Conserved Coronavirus Epitopes

This study designs engineered immunogens targeting conserved coronavirus epitopes to elicit broad-spectrum antibodies, showing protection in mice against live virus challenge.

Mutation-Guided Vaccine Design: A Strategy for Developing Boosting Immunogens for HIV Broadly Neutralizing Antibody Induction

The paper demonstrates a mutation-guided vaccine strategy that induces HIV broadly neutralizing antibodies in mice by selecting for rare B cell lineage mutations.

A germline-targeting chimpanzee SIV envelope glycoprotein elicits a new class of V2-apex directed cross-neutralizing antibodies

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

Allosteric activation of CRISPR-Cas12a requires the concerted movement of the bridge helix and helix 1 of the RuvC II domain

This study investigates the role of helix 1 and the bridge helix in the allosteric activation of FnCas12a by showing their coordinated movement is essential for lid opening and DNA cleavage.

Breadth of SARS-CoV-2 Neutralization and Protection Induced by a Nanoparticle Vaccine

This study shows a nanoparticle vaccine induces broad neutralizing antibodies against multiple SARS-CoV-2 variants and protects non-human primates and mice from viral challenges.

Ability of nucleoside-modified mRNA to encode HIV-1 envelope trimer nanoparticles

This study shows that nucleoside-modified mRNA can encode HIV-1 Env trimer nanoparticles that induce bnAb precursor B cell expansion and neutralizing activity in mice.

Acute stressors experienced by layer breeders do not affect measures of stress and fear in their offspring

This study tests if maternal stress affects offspring stress and fear responses in layer breeders, finding no effect of acute stressors or corticosterone on offspring measures, but significant strain differences.

Chimpanzee SIV Envelope trimer: structure and deployment as an HIV vaccine template

The paper describes the structure of a chimpanzee SIV Env trimer and shows it induces HIV V2-specific neutralizing antibodies in mice.