Innate immune memory after brain injury drives inflammatory cardiac dysfunction
A. Simats, S. Zhang, D. Messerer, J. Cao, F. Chong, S. Besson-Girard, O. Carofiglio, S. Filser, N. Plesnila, C. Braun, O. Gokce, M. Dichgans, K. Hatakeyama, B. Bonev, E. Beltran, , A. Liesz
This study identifies innate immune memory after brain injury as a driver of chronic cardiac dysfunction, showing that post-stroke epigenetic changes in myeloid cells lead to inflammation and fibrosis in the heart.
bioRxiv · Oct 4, 2023Immunology