D. Pinto

Inclusion of Salicornia ramosissima biomass in diets for juvenile whiteleg shrimp (Penaeus vannamei) induces favourable but transient effects in the immune and oxidative status

This study evaluates the effects of including Salicornia ramosissima biomass in shrimp diets on growth, immune status, and oxidative stress, finding transient improvements in antioxidant response and potential cost savings.

Therapeutic and vaccine-induced cross-reactive antibodies with effector function against emerging Omicron variants

The paper shows that cross-reactive antibodies, like S309, retain effector functions against emerging Omicron variants despite reduced neutralization.

Imprinted antibody responses against SARS-CoV-2 Omicron sublineages

This study shows that hybrid immunity and vaccine boosters provide potent neutralizing activity against Omicron BA.1 and BA.2, while breakthrough infections induce nasal mucosal neutralization and identify an ultrapotent pan-variant antibody.

ACE2 engagement exposes the fusion peptide to pan-coronavirus neutralizing antibodies

The paper identifies monoclonal antibodies that neutralize multiple coronaviruses by targeting the fusion peptide, which becomes exposed upon ACE2 engagement.

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

This study shows that Omicron variant's spike protein has enhanced ACE2 binding and reduces neutralizing activity, but some broadly neutralizing antibodies remain effective.

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

This study identifies a broadly neutralizing antibody against sarbecoviruses that targets the ACE2 binding site and shows high resistance to escape mutations.

A human antibody that broadly neutralizes betacoronaviruses protects against SARS-CoV-2 by blocking the fusion machinery

This paper identifies a human antibody that broadly neutralizes betacoronaviruses by targeting the stem helix, showing protection against SARS-CoV-2 and potential for vaccine design.

Structural basis for broad sarbecovirus neutralization by a human monoclonal antibody

This paper identifies a human monoclonal antibody that broadly neutralizes SARS-CoV-2 variants and zoonotic sarbecoviruses by targeting a conserved epitope on the spike protein.

Antibodies to the SARS-CoV-2 receptor-binding domain that maximize breadth and resistance to viral escape

This study identifies antibodies against SARS-CoV-2 that balance neutralization potency and breadth, with some showing high resistance to viral escape.

SARS-CoV-2 immune evasion by variant B.1.427/B.1.429

This study evaluates how the B.1.427/B.1.429 SARS-CoV-2 variant evades neutralizing antibodies through mutations in the RBD and NTD, showing reduced neutralization by both vaccine-induced and infection-derived antibodies.

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

This paper evaluates the in vitro and in vivo efficacy of dual-action monoclonal antibodies VIR-7831 and VIR-7832 against SARS-CoV-2, showing potent neutralization and reduced viral load in a hamster model.

N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2

The paper identifies a conserved antigenic supersite on the SARS-CoV-2 N-terminal domain recognized by neutralizing antibodies and shows its vulnerability to mutations in variants.

The circulating SARS-CoV-2 spike variant N439K maintains fitness while evading antibody-mediated immunity

The paper shows the N439K SARS-CoV-2 spike variant maintains replication fitness while evading antibody neutralization.

Structural and functional analysis of a potent sarbecovirus neutralizing antibody

This study identifies and characterizes a potent neutralizing antibody, S309, against SARS-CoV-2 and related sarbecoviruses, showing its efficacy in preventing viral entry and potential for therapeutic use.