A. Joshi

Quantifying evidence for phenotypic specificity (PP4) for syndromic phenotypes: Large-scale integration of rare germline FH variants from diagnostic laboratory testing for HLRCC (Hereditary Leiomyomatosis and Renal Cell Cancer) and renal cancer

The paper quantifies phenotypic specificity of rare FH variants in HLRCC and renal cancer using likelihood ratios from clinical and population data.

Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions into amyloid fibrils

This study shows that Ydj1, a heat shock protein 40, prevents amyloid fibril formation by promoting heterotypic phase separation of tau through electrostatic and hydrophobic interactions.

Intermolecular Energy Migration via HomoFRET Captures the Modulation in the Material Property of Phase-Separated Biomolecular Condensates

This study uses homoFRET to measure material property changes in biomolecular condensates, showing how factors like RNA and post-translational modifications affect their structure.

Phytochemical Characterization of Bio-active Compounds in Hydroethanolic Extract of Elaeocarpus ganitrus leaves using HPLC, LC-MS, and HPTLC Analyses

This study characterizes bioactive compounds in Elaeocarpus ganitrus leaves using HPLC, LC-MS, and HPTLC, identifying 93 compounds with potential therapeutic applications.

NVX-CoV2373 ancestral and NVX-CoV2540 BA.5 protein nanoparticle vaccines protect against Omicron BA.5 variant in Syrian hamsters

This study evaluates the efficacy of NVX-CoV2373 and NVX-CoV2540 nanoparticle vaccines against the Omicron BA.5 variant in Syrian hamsters, showing reduced viral infection and better protection compared to mRNA vaccines.

An individual-based simulation framework exploring the ecology and mechanistic underpinnings of larval crowding in laboratory populations of Drosophila

The paper develops an individual-based simulation framework to explore how feeding band density influences larval competition and evolutionary outcomes in Drosophila cultures.

More than just density: the role of egg number, food volume and container dimensions in mediating larval competition in Drosophila melanogaster

This study shows that larval competition in Drosophila melanogaster depends on egg number, food volume, and container dimensions, not just density, and introduces effective density as a better metric.

The role of greater competitive ability in countering age disadvantages in larval competition in Drosophila melanogaster

This study shows that Drosophila melanogaster populations adapted to larval crowding better counter age disadvantages in competition than low-density controls, but differences in egg size and hatching time among these populations do not improve their performance against age-disadvantaged competitors.

The evolution of competitive effectiveness and tolerance in populations of Drosophila melanogaster adapted to chronic larval crowding at varying combinations of egg number and food volume

This study examines how competitive effectiveness and tolerance evolve in Drosophila melanogaster under different chronic larval crowding conditions and finds they vary with selection regime and outcome traits.

The highly conserved stem-loop II motif is dispensable for SARS-CoV-2

This study shows that the stem-loop II motif in SARS-CoV-2 is not essential for viral growth in vitro or in vivo.

Single-Molecule FRET Illuminates Structural Subpopulations and Dissects Crucial Molecular Events During Phase Separation of a Prion-Like Low Complexity Domain

The paper uses single-molecule techniques to study phase separation of a prion-like domain, revealing structural subpopulations and molecular events involved in condensate formation and disease-related aggregation.

ATP modulates self-perpetuating conformational conversion generating structurally distinct yeast prion amyloids that limit autocatalytic amplification

This study shows ATP modulates yeast prion amyloid formation and limits autocatalytic amplification by altering aggregate structure and fragmentation.

Nucleoid-Associated Proteins Undergo Liquid-Liquid Phase Separation with DNA into Multiphasic Condensates Resembling Bacterial Nucleoids

The paper shows NAPs like HU-A, HU-B, and Dps form multiphasic condensates with DNA, resembling bacterial nucleoids through phase separation.

Medulloblastoma Group 3 and 4 Tumors Comprise a Clinically and Biologically Significant Expression Continuum Reflecting Human Cerebellar Development

The paper shows medulloblastoma Group3 and Group4 tumors form a transcriptional continuum linked to cerebellar development, with prognostic and molecular implications.

Density-dependent selection at high food levels leads to the evolution of persistence but not constancy in Drosophila melanogaster populations

This study shows that Drosophila melanogaster populations evolve higher persistence stability than controls under density-dependent selection at high food levels, but not constancy stability.

Density-dependent selection at low food levels leads to the evolution of population stability in Drosophila melanogaster even without a clear r-K trade-off

This study shows that Drosophila melanogaster populations adapted to larval crowding at low food levels evolve greater population stability through increased K and reduced density sensitivity, without a clear r-K trade-off.

Effects of larval and adult crowding on fitness components in Drosophila populations adapted to larval crowding experienced under different combinations of food amount and egg number

This study examines how larval and adult crowding affect fitness components in two sets of Drosophila melanogaster populations adapted to larval crowding under different food conditions, finding that pre-adult survivorship responds differently to larval density.

ACE2 engagement exposes the fusion peptide to pan-coronavirus neutralizing antibodies

The paper identifies monoclonal antibodies that neutralize multiple coronaviruses by targeting the fusion peptide, which becomes exposed upon ACE2 engagement.

Prevalence of Bourbon and Heartland viruses in field collected ticks at an environmental field station in St. Louis County, Missouri, USA

The study assesses the prevalence of Bourbon and Heartland viruses in ticks at an environmental field station, finding 3.9% and 7.6% positivity rates respectively.

Single-Droplet Surface-Enhanced Raman Scattering Decodes the Molecular Language of Liquid-Liquid Phase Separation

This study uses single-droplet SERS to analyze molecular interactions in FUS condensates, revealing conformational heterogeneity and RNA effects.

Ocimum sanctum, OscWRKY1, regulates phenylpropanoid pathway genes and promotes resistance to pathogen infection in Arabidopsis

This study identifies OscWRKY1 from Ocimum sanctum as a regulator of the phenylpropanoid pathway and pathogen resistance in Arabidopsis through direct binding to W-box cis-elements.

AtERF60, negatively regulates ABR1 to modulate basal resistance response in Arabidopsis

This study identifies AtERF60 as a regulator of ABR1, showing that AtERF60 overexpression enhances basal resistance to PstDC3000 while its mutation increases susceptibility.

mRNA-1273 and Ad26.COV2.S vaccines protect against the B.1.621 variant of SARS-CoV-2

This study evaluates the efficacy of mRNA-1273 and Ad26.COV2.S vaccines against the B.1.621 variant in mice and hamsters, showing protection against infection and pathology.

SARS-CoV-2 spike conformation determines plasma neutralizing activity

This study shows that vaccines encoding a prefusion-stabilized SARS-CoV-2 spike protein induce higher neutralizing antibody titers and better variant cross-neutralization compared to other vaccines or infection.

Temporal in vivo platelet labelling in mice reveals age-dependent receptor expression and conservation of specific mRNAs

This study uses in vivo temporal labeling to show age-dependent changes in mouse platelet function and mRNA conservation.

Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses

The paper examines antibody responses in Delta breakthrough infections, finding they are more potent, durable, and broad compared to vaccinated-only or infected-only individuals.

Structure, receptor recognition and antigenicity of the human coronavirus CCoV-HuPn-2018 spike glycoprotein

The paper determines the structure of the CCoV-HuPn-2018 spike glycoprotein, identifies its receptor, and shows cross-neutralizing antibodies against related coronaviruses.

Density-dependent selection in Drosophila: evolution of egg size and hatching time

This study shows that egg size and hatching time evolve in response to different larval crowding regimes in Drosophila, with egg size consistently correlating with increased competitive ability.

Antibody-mediated broad sarbecovirus neutralization through ACE2 molecular mimicry

This study identifies a broadly neutralizing antibody against sarbecoviruses that targets the ACE2 binding site and shows high resistance to escape mutations.

Proteome and functional decline as platelets age in the circulation

The paper investigates age-related changes in platelets, finding reduced protein content, altered proteomic pathways, and functional decline in older platelets.