Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
16 papers
Recent·Most cited
M. McCallum, Y.-J. Park, C. Stewart, K. R. Sprouse, J. Brown, M. A. Tortorici, C. Gibson, E. Wong, M. Ieven, A. Telenti, D. Veesler
This study determines the structure of HKU1 spike RBD bound to TMPRSS2, identifies host receptor usage determinants, and shows the role of antibodies and glycan shielding in neutralization.
Cell · Aug 1, 2024Peer-reviewedBiochemistry
M. Rexhepaj, Y.-J. Park, L. Perruzza, D. Asarnow, M. McCallum, K. Culap, C. Saliba, G. Leoni, A. Balmeli, C. Yoshiyama, M. S. Dickinson, J. Quispe, J. T. Brown, M. A. Tortorici, K. R. Sprouse, , D. Veesler
The paper isolates two human monoclonal antibodies that broadly neutralize PDCoV variants and identifies their mechanism of action.
bioRxiv · Mar 27, 2024 · PreprintBiochemistry
Z. Wang, M. McCallum, L. Yan, W. Sharkey, Y.-J. Park, H. V. Dang, M. Amaya, A. Person, C. C. Broder, D. J. Veesler
The paper determines the structure of Langya virus glycoproteins and shows they use a different receptor than NiV and HeV, with no cross-reactivity of antibodies.
bioRxiv · Aug 20, 2023Biochemistry
R. Marzi, J. Bassi, C. Silacci-Fregni, I. Bartha, F. Muoio, K. Culap, N. Sprugasci, G. Lombardo, C. Saliba, E. Cameroni, A. Cassotta, J. S. Low, A. C. Walls, M. McCallum, M. A. Tortorici, , L. Piccoli
The paper examines the kinetics, avidity, and cross-reactivity of SARS-CoV-2-specific memory B cells and antibodies in infected and vaccinated individuals over 16 months, finding that MBC maturation enhances resilience to viral escape.
bioRxiv · Sep 30, 2022Immunology
J. S. Low, J. Jerak, M. A. Tortorici, M. McCallum, D. Pinto, A. Cassotta, M. Foglierini, F. Mele, R. Abdelnabi, B. Weynand, J. Noack, M. Montiel-Ruiz, S. Bianchi, F. Benigni, N. Sprugasci, , F. Sallusto
The paper identifies monoclonal antibodies that neutralize multiple coronaviruses by targeting the fusion peptide, which becomes exposed upon ACE2 engagement.
bioRxiv · Mar 30, 2022Immunology
T. N. Starr, A. J. Greaney, W. W. Hannon, A. N. Loes, K. Hauser, J. R. Dillen, E. Ferri, A. Ghez Farrell, B. Dadonaite, M. McCallum, K. A. Matreyek, D. Corti, D. Veesler, G. Snell, J. D. Bloom
The paper analyzes epistatic shifts in SARS-CoV-2 RBD mutations across variants to understand how they influence ACE2 binding and future evolution.
bioRxiv · Feb 24, 2022Microbiology
M. McCallum, N. Czudnochowski, L. E. Rosen, S. K. Zepeda, J. E. Bowen, J. R. Dillen, A. Powell, T. Croll, J. Nix, H. W. Virgin, D. Corti, G. Snell, D. Veesler
This study determines the structural basis of SARS-CoV-2 Omicron's immune evasion and receptor engagement through cryo-EM and X-ray crystal structures of the spike and RBD bound to antibodies and ACE2.
bioRxiv · Dec 28, 2021Biochemistry
A. C. Walls, K. R. Sprouse, A. Joshi, J. E. Bowen, N. Franko, M.-J. Navarro, C. Stewart, M. McCallum, E. A. Goecker, E. J. Degli-Angeli, J. Logue, A. Greninger, H. Chu, D. Veesler
The paper examines antibody responses in Delta breakthrough infections, finding they are more potent, durable, and broad compared to vaccinated-only or infected-only individuals.
bioRxiv · Dec 8, 2021 · PreprintImmunology
M. McCallum, A. C. Walls, K. R. Sprouse, J. E. Bowen, L. Rosen, H. V. Dang, A. deMarco, N. Franko, S. W. Tilles, J. Logue, M. C. Miranda, M. Ahlrichs, L. Carter, G. Snell, M. S. Pizzuto, , D. Veesler
This study investigates how delta and kappa SARS-CoV-2 variants evade immune responses by altering antigenic sites and reducing ACE2 binding affinity.
bioRxiv · Aug 11, 2021Immunology
M. McCallum, J. Bassi, A. De Marco, A. Chen, A. C. Walls, J. Di Iulio, M. A. Tortorici, M.-J. Navarro, C. Silacci-Fregni, C. Saliba, M. Agostini, D. Pinto, K. Culap, S. Bianchi, S. Jaconi, , D. Veesler
This study evaluates how the B.1.427/B.1.429 SARS-CoV-2 variant evades neutralizing antibodies through mutations in the RBD and NTD, showing reduced neutralization by both vaccine-induced and infection-derived antibodies.
bioRxiv · Mar 31, 2021 · PreprintImmunology
M. McCallum, A. De Marco, F. Lempp, M. A. Tortorici, D. Pinto, A. C. Walls, M. Beltramello, A. Chen, Z. Liu, F. Zatta, S. Zepeda, J. di Iulio, J. E. Bowen, M. Montiel-Ruiz, J. Zhou, , D. Veesler
The paper identifies a conserved antigenic supersite on the SARS-CoV-2 N-terminal domain recognized by neutralizing antibodies and shows its vulnerability to mutations in variants.
bioRxiv · Jan 14, 2021Immunology
M. McCallum, A. C. Walls, D. Corti, D. Veesler
This paper designs a stabilized SARS-CoV-2 spike glycoprotein in the closed conformation, showing it maintains structure and antigenicity while being applicable to other beta-coronaviruses.
bioRxiv · Jun 3, 2020 · PreprintBiochemistry
M. McCallum, S. Tammam, J. L. Rubinstein, L. L. Burrows, P. L. Howell
The paper determines the structure of PilQ from Pseudomonas aeruginosa and identifies TsaP as the spoke-forming component, revealing its role in surface-sensing signal transduction.
bioRxiv · May 29, 2020Microbiology
M. McCallum, S. Benlekbir, S. Nguyen, S. Tammam, J. L. Rubinstein, L. L. Burrows, P. L. Howell
The paper determines four X-ray structures of PilT in different conformations and validates their physiological importance through co-evolution analysis and functional studies.
bioRxiv · Jun 15, 2019Microbiology
R. Jordan, J. R. Milanovich, M. McCallum, S. E. Trauth
This study tests homing ability and egg discrimination in western slimy salamanders, finding that females return to their nests and discriminate between their own and unfamiliar eggs.
bioRxiv · Aug 9, 2018 · PreprintAnimal Behavior & Cognition