Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks
M. Dudek, D. Pathiranage, C. F. Goncalves, C. Lawless, D. Wang, Z. Luo, L. Yang, F. Guilak, J. A. Hoyland, Q.-J. Meng
The paper shows mechanical loading and hyperosmolarity reset circadian clocks in skeletal tissues via the mTORC2-AKT-GSK3β pathway, inducing rhythmic gene expression.
bioRxiv · Oct 1, 2021Physiology