C. Lawless

A stagewise response to mitochondrial dysfunction in mitochondrial DNA maintenance disorders

The paper investigates the cellular response to mitochondrial dysfunction in mtDNA maintenance disorders using imaging mass cytometry, finding complex-specific upregulation and proteostasis activation.

Optimising a self-assembling peptide hydrogel as a Matrigel alternative for 3-dimensional mammary epithelial cell culture

This study optimizes self-assembling peptide hydrogels to better support mammary epithelial cell organoid formation compared to Matrigel.

Proximity mapping of desmosomes reveals a striking shift in their molecular neighbourhood associated with maturation

The paper maps the molecular neighbourhood of desmosomes during maturation, revealing distinct roles of desmosomal proteins in cellular signalling.

Modelling collagen fibril self-assembly from extracellular medium in embryonic tendon

The paper models collagen fibril self-assembly in embryonic mouse tendon, showing that fibrils form extracellularly through a phase-transition mechanism, supported by experimental data.

Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans

The paper analyzes chemokine gene expression across species, tissues, and diseases, showing complex patterns and demonstrates that ECM proteoglycans modulate chemokine signaling and leukocyte recruitment.

The UIP honeycomb airway cells are the site of mucin biogenesis with deranged cilia

The paper uses spatial proteomics to compare fibrotic and non-fibrotic airway cells in UIP, finding deregulated pathways and identifying key proteins associated with mucin biogenesis and ciliogenesis.

Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families

The paper uses proximity labeling to identify protein complexes associated with Rab4, Rab11a, and Rab25 in cancer cells, revealing their roles in endocytic recycling and cell migration.

Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex

The paper identifies MAVS as a client of the BAG6 complex, showing its role in quality control and innate immune response modulation.

The IPF fibroblastic focus is an active collagen biosynthesis factory embedded in a distinct extracellular matrix

The paper uses spatial proteomics to show that the IPF fibroblastic focus is a major site of collagen biosynthesis with distinct ECM composition compared to surrounding tissues.

A basement membrane discovery pipeline uncovers network complexity, new regulators, and human disease associations

The paper develops a pipeline to identify BM-associated proteins, finds new regulators, and links BM genes to human disease.

Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks

The paper shows mechanical loading and hyperosmolarity reset circadian clocks in skeletal tissues via the mTORC2-AKT-GSK3β pathway, inducing rhythmic gene expression.

Kidney organoids: A system to study human basement membrane assembly in health and disease

This study uses kidney organoids to investigate basement membrane assembly dynamics, identifying conserved temporal patterns and pathogenic variant effects.

IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection

This study shows that IL-13 reduces lung damage and supports epithelial type 2 molecule production during nematode infection in mice.

Quantifying variation in bacterial reproductive fitness with and without antimicrobial resistance: a high-throughput method

This paper introduces baQFA, a low-cost high-throughput method to quantify bacterial reproductive fitness with and without antimicrobial resistance using time-lapse imaging and Gompertz modeling.

Definition of the fibroblast adhesome using multiplexed proximity biotinylation

The paper defines the fibroblast adhesome using multiplexed proximity biotinylation and identifies functional modules within integrin adhesion complexes.

Circadian time series proteomics reveals daily dynamics in cartilage physiology

This study uses circadian time-series proteomics to identify daily protein abundance changes in mouse articular cartilage, revealing rhythmic proteins and their dysregulation in osteoarthritis and aging.