M. Dudek

Modulation of circadian rhythms in articular cartilage by heat pulses

This study shows that heat pulses can restore circadian rhythms in cartilage by modulating heat shock proteins and circadian clock genes.

The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc

This study shows that BMAL1, a circadian clock factor, regulates ECM homeostasis and cell fate in the intervertebral disc, with its loss causing ECM dysregulation and osteogenic differentiation.

Acinar-to-ductal metaplasia in the pancreas requires a glycolytic switch and functional mitochondria

This study identifies a glycolytic switch and functional mitochondria as essential for acinar-to-ductal metaplasia, a key step in pancreatic carcinogenesis.

Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks

The paper shows mechanical loading and hyperosmolarity reset circadian clocks in skeletal tissues via the mTORC2-AKT-GSK3β pathway, inducing rhythmic gene expression.

The Ufm1 system is upregulated by ER stress during osteogenic differentiation

The paper investigates the upregulation of the Ufm1 system during osteogenic differentiation and ER stress, linking it to skeletal dysplasia caused by UFSP2 mutations.

Circadian time series proteomics reveals daily dynamics in cartilage physiology

This study uses circadian time-series proteomics to identify daily protein abundance changes in mouse articular cartilage, revealing rhythmic proteins and their dysregulation in osteoarthritis and aging.