Loss of PTPMT1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice
H. Zheng, Q. Li, S. Li, Z. Li, M. Brotto, D. Weiss, D. Prosdocimo, C. Xu, A. Reddy, M. Puchowicz, X. Zhao, M. N. Weitzmann, M. K. Jain, C.-K. Qu
This study shows that PTPMT1 deletion in skeletal muscle and heart causes metabolic inflexibility, leading to atrophy, heart failure, and death, while liver and adipose tissue deletion has no effect.
bioRxiv · Jan 9, 2023 · PreprintCell Biology