Author

M. Brotto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1 Assay:proteomics· 1

Frequent Co-Authors

C. P. Cardozo· 2 shared R. De Gasperi· 2 shared A. Aslan· 1 shared A. M. Raczkowski· 1 shared A. Reddy· 1 shared B. Dienes· 1 shared B. Zhang· 1 shared C. A. Toro· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersPhysiology

C. P. Cardozo

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Septin 7 Interacts With Numb To Preserve Sarcomere Structural Organization And Muscle Contractile Function.

R. De Gasperi, L. Csernoch, B. Dienes, M. Gonczi, J. K. Chakrabarty, S. Goeta, A. Aslan, C. A. Toro, D. Karasik, L. M. Brown, M. Brotto, C. P. Cardozo

The paper identifies Septin 7 as a Numb binding partner that helps maintain sarcomere structure and muscle function in aging skeletal muscle.

bioRxiv · May 11, 2023Physiology

Loss of PTPMT1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice

H. Zheng, Q. Li, S. Li, Z. Li, M. Brotto, D. Weiss, D. Prosdocimo, C. Xu, A. Reddy, M. Puchowicz, X. Zhao, M. N. Weitzmann, M. K. Jain, C.-K. Qu

This study shows that PTPMT1 deletion in skeletal muscle and heart causes metabolic inflexibility, leading to atrophy, heart failure, and death, while liver and adipose tissue deletion has no effect.

bioRxiv · Jan 9, 2023 · PreprintCell Biology

Numb is required for optimal contraction of skeletal muscle

R. De Gasperi, C. Mo, D. Azulai, Z. Wang, L. M. Harlow, Y. Du, Z. A. Graham, X.-h. Liu, L. Guo, B. Zhang, F. Ko, A. M. Raczkowski, W. A. Bauman, W. Zhao, M. Brotto, C. P. Cardozo

This study shows that Numb is essential for skeletal muscle function, as its knockout reduces force, alters mitochondrial structure, and affects calcium dynamics in mice.

Journal of Cachexia, Sarcopenia and Muscle · Jan 9, 2022Peer-reviewedPhysiology