Author

M. Puchowicz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:metabolism & bioenergetics· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Yu· 2 shared D. Bhattacharya· 2 shared H. Chen· 2 shared P. Ranea-Robles· 2 shared S. Houten· 2 shared S. L. Friedman· 2 shared A. Reddy· 1 shared B. Stauffer· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersPhysiology

C. Yu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Loss of PTPMT1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice

H. Zheng, Q. Li, S. Li, Z. Li, M. Brotto, D. Weiss, D. Prosdocimo, C. Xu, A. Reddy, M. Puchowicz, X. Zhao, M. N. Weitzmann, M. K. Jain, C.-K. Qu

This study shows that PTPMT1 deletion in skeletal muscle and heart causes metabolic inflexibility, leading to atrophy, heart failure, and death, while liver and adipose tissue deletion has no effect.

bioRxiv · Jan 9, 2023 · PreprintCell Biology

The peroxisomal transporter ABCD3 plays a major role in dicarboxylic fatty acid metabolism

P. Ranea-Robles, H. Chen, B. Stauffer, C. Yu, D. Bhattacharya, S. L. Friedman, M. Puchowicz, S. Houten

This study investigates the role of ABCD3 in DCA metabolism using an Abcd3 KO mouse model and shows its impact on lipid homeostasis and metabolic compartmentalization.

bioRxiv · Jul 26, 2021Physiology

Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis

P. Ranea-Robles, S. Violante, C. Argmann, T. Dodatko, D. Bhattacharya, H. Chen, C. Yu, S. L. Friedman, M. Puchowicz, S. Houten

This study investigates the role of EHHADH in DCA β-oxidation and its impact on hepatic cholesterol homeostasis in mice, finding that EHHADH deficiency leads to 3-hydroxydicarboxylic aciduria and altered cholesterol synthesis.

bioRxiv · Mar 2, 2021Physiology

Mice Lacking FXR Are Susceptible to Liver Ischemia-Reperfusion Injury

Y. Li, R. Xu, P. K. Rao, C. K. Gomes, E. R. Moran, M. Puchowicz, E. B. Chang, D. P. Yin, J. F. Pierre

This study shows that FXR deficiency increases liver damage and inflammation during ischemia-reperfusion injury, with altered bile acid metabolism and gut microbiota composition.

bioRxiv · Aug 19, 2019 · PreprintPhysiology