D. Weiss

Temperate bacteriophage induced in Pseudomonas aeruginosa biofilms can modulate bacteriophage and antibiotic resistance

The paper examines Pseudomonas aeruginosa isolates from cystic fibrosis patients to assess prophage presence and their impact on phage and antibiotic resistance.

Serum Proteome Profiling Identifies N-Cadherin and C-Met as Early Marker Candidates of Therapeutic Response to Neoadjuvant Chemotherapy in Breast Cancer

Mechanosensing through talin 1 contributes to tissue mechanical homeostasis

This study shows that mutations in talin1 alter cellular stiffness sensing, leading to changes in ECM mechanical properties and aortic compliance.

Red light perception by the root is essential for gibberellin-induced primary-root elongation in tomato

This study shows that red light perception by roots is essential for gibberellin-induced primary-root elongation in tomato, suggesting light-dependent GA signaling regulates root growth.

A fast, robust method for quantitative assessment of collagen fibril architecture from transmission electron micrographs

The paper introduces a semi-automated method to quantify collagen fibril architecture from TEM images, validated on mouse aortic samples.

Loss of PTPMT1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice

This study shows that PTPMT1 deletion in skeletal muscle and heart causes metabolic inflexibility, leading to atrophy, heart failure, and death, while liver and adipose tissue deletion has no effect.

Compensatory aortic remodeling in Marfan syndrome protects against sexually dimorphic rupture during a BAPN challenge

The paper examines sexual dimorphism in aortic remodeling and rupture resistance in Marfan syndrome mice with and without BAPN exposure, finding compensatory mechanisms in females and males that protect against rupture.

Human Lung-resident Mucosal-Associated Invariant T cells are Abundant, Express Antimicrobial Proteins, and are Cytokine Responsive

The paper identifies and characterizes lung-resident MAIT cells, showing they express antimicrobial proteins and are cytokine responsive.

ABA-IMPORTING TRANSPORTER 1.1 activity in the endosperm of tomato seeds restrains germination under salinity stress

This study shows that AIT1.1 in tomato endosperm mediates ABA uptake to restrain germination under salinity stress, with ait1.1 mutants showing improved germination.

Uncertainty quantification in subject-specific estimation of local vessel mechanical properties

The paper introduces an uncertainty quantification method for estimating local vessel mechanical properties using Bayesian techniques and applies it to mouse aorta data.

Underground gibberellin activity: differential gibberellin response in tomato shoots and roots

This study investigates the differential response to gibberellin (GA) in tomato shoots and roots, finding that GA receptors are less expressed in roots, leading to weaker GA effects on root elongation compared to shoots.

The tomato DELLA protein PROCERA promotes ABA responses in guard cells by upregulating ABA transporter

The paper shows that the tomato DELLA protein PROCERA enhances ABA-induced stomatal closure by upregulating the ABA transporter AIT1.1 in guard cells.

Mutations in the tomato gibberellin receptors suppresses xylem proliferation and reduces water loss under water-deficit conditions

This study shows that mutating GID1 receptors in tomato reduces xylem proliferation and hydraulic conductance, leading to reduced water loss under drought.

Paradoxical Aortic Stiffening and Subsequent Cardiac Dysfunction in Hutchinson-Gilford Progeria Syndrome

This study shows that aortic stiffening and cardiac dysfunction in HGPS mice occur due to loss of smooth muscle function and proteoglycan accumulation, independent of sex, with potential therapeutic implications.

Highly Efficient, Massively-Parallel Single-Cell RNA-Seq Reveals Cellular States and Molecular Features of Human Skin Pathology

The paper introduces an improved scRNA-Seq protocol, Seq-Well S^3, which enhances transcript capture and gene detection efficiency, and applies it to study inflammatory skin diseases.