Author

D. Roderer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 4 Approach:experimental assay· 3 Approach:biophysical modeling· 2 Approach:deep learning· 2 Organism:human· 2 Assay:protein structure· 2 Organism:Arabidopsis· 1 Research Focus:benchmarking· 1

Frequent Co-Authors

S. Raunser· 5 shared O. Sitsel· 3 shared A. Belyy· 2 shared D. Prumbaum· 2 shared E. Schubert· 2 shared A. Apelbaum· 1 shared A. Di Cicco· 1 shared A. Hovasse· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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5 shared papersBiochemistry

S. Raunser

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural basis of Fusobacterium nucleatum adhesin Fap2 interaction with receptors on cancer and immune cells

F. Schöpf, G. L. Marongiu, K. Milaj, T. Sprink, J. Kikhney, A. Moter, D. Roderer

This study determines the structural basis of Fusobacterium nucleatum adhesin Fap2 interactions with Gal-GalNAc and TIGIT, revealing binding mechanisms and structural details.

bioRxiv · Feb 28, 2024 · PreprintBiochemistry

Multi-state kinetics of the syringe-like injection mechanism of Tc toxins

P. N. Ng`ang`a, J. Folz, S. Kucher, D. Roderer, Y. Xu, O. Sitsel, A. Belyy, D. Prumbaum, R. Kuehnemuth, T. E. Assafa, M. Dong, C. A. M. Seidel, E. Bordignon, S. Raunser

This study investigates the multi-state kinetics of Tc toxin prepore-to-pore transition, identifying intermediate states and transition times under various conditions.

bioRxiv · Jan 16, 2024 · PreprintBiochemistry

Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate α

M. Shafaq-Zadah, E. Dransart, C. Wunder, V. Chambon, C. A. Valades-Cruz, L. Leconte, N. Kumar Sarangi, J. Robinson, S.-K. Bai, R. Regmi, A. Di Cicco, A. Hovasse, R. Bartels, U. Nilsson, S. Cianferani-Sanglier, , L. Johannes

The paper identifies how spatial N-glycan rearrangements on α5β1 integrin nucleate galectin-3 oligomers, determining endocytic fate and retrograde trafficking.

bioRxiv · Oct 27, 2023 · PreprintCell Biology

Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin

A. Belyy, F. Lindemann, D. Roderer, J. Funk, B. Bardiaux, J. Protze, P. Bieling, H. Oschkinat, S. Raunser

This study reveals how TccC3 toxin modifies F-actin by ADP-ribosylating threonine-148, disrupting actin dynamics and causing cell death.

bioRxiv · May 6, 2022Biochemistry

Towards the application of Tc toxins as a universal protein translocation system

D. Roderer, E. Schubert, O. Sitsel, S. Raunser

The paper demonstrates that Tc toxins can be modified to deliver various small proteins across membranes using a combination of experimental techniques.

bioRxiv · Jul 18, 2019Biochemistry

SPHIRE-crYOLO: A fast and accurate fully automated particle picker for cryo-EM

T. Wagner, F. Merino, M. Stabrin, T. Moriya, C. Antoni, A. Apelbaum, P. Hagel, O. Sitsel, T. Raisch, D. Prumbaum, D. Quentin, D. Roderer, S. Tacke, B. Siebolds, E. Schubert, , S. Raunser

The paper introduces crYOLO, a deep learning-based particle picker for cryo-EM that achieves high accuracy and speed, enabling automated data pre-processing.

bioRxiv · Mar 13, 2019Biophysics