Author

O. Sitsel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Organism:Arabidopsis· 1 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Approach:biophysical modeling· 1 Assay:cryo-EM· 1 Approach:deep learning· 1

Frequent Co-Authors

S. Raunser· 5 shared D. Roderer· 3 shared D. Prumbaum· 2 shared D. Quentin· 2 shared E. Schubert· 2 shared F. Merino· 2 shared M. Stabrin· 2 shared T. Wagner· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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5 shared papersBiochemistry

S. Raunser

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multi-state kinetics of the syringe-like injection mechanism of Tc toxins

P. N. Ng`ang`a, J. Folz, S. Kucher, D. Roderer, Y. Xu, O. Sitsel, A. Belyy, D. Prumbaum, R. Kuehnemuth, T. E. Assafa, M. Dong, C. A. M. Seidel, E. Bordignon, S. Raunser

This study investigates the multi-state kinetics of Tc toxin prepore-to-pore transition, identifying intermediate states and transition times under various conditions.

bioRxiv · Jan 16, 2024 · PreprintBiochemistry

Specialized pathogenic cells release Tc toxins using a type 10 secretion system

O. Sitsel, Z. Wang, P. Janning, L. Kroczek, T. Wagner, S. Raunser

The paper identifies a type 10 secretion system in Yersinia entomophaga that releases Tc toxins via controlled cell lysis, revealing a novel lytic mechanism for toxin export.

bioRxiv · Feb 22, 2023 · PreprintMicrobiology

Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

D. Vinayagam, D. Quentin, O. Sitsel, F. Merino, M. Stabrin, O. Hofnagel, M. Yu, M. W. Ledeboer, G. Malojcic, S. Raunser

The paper reports structures of TRPC4 in complex with inhibitors, activators, and calmodulin, revealing how ligand binding and calmodulin interaction regulate the channel's conformation.

bioRxiv · Jun 30, 2020Biochemistry

Towards the application of Tc toxins as a universal protein translocation system

D. Roderer, E. Schubert, O. Sitsel, S. Raunser

The paper demonstrates that Tc toxins can be modified to deliver various small proteins across membranes using a combination of experimental techniques.

bioRxiv · Jul 18, 2019Biochemistry

SPHIRE-crYOLO: A fast and accurate fully automated particle picker for cryo-EM

T. Wagner, F. Merino, M. Stabrin, T. Moriya, C. Antoni, A. Apelbaum, P. Hagel, O. Sitsel, T. Raisch, D. Prumbaum, D. Quentin, D. Roderer, S. Tacke, B. Siebolds, E. Schubert, , S. Raunser

The paper introduces crYOLO, a deep learning-based particle picker for cryo-EM that achieves high accuracy and speed, enabling automated data pre-processing.

bioRxiv · Mar 13, 2019Biophysics