T. Wagner

A high-throughput and sensitive method for food preference assays in the Argentine ant

This paper introduces a high-throughput dual-choice feeder method to measure food preference in Argentine ants, showing it can detect lower quinine aversion levels than traditional methods.

Butyrate and propionate are microbial danger signals that activate the NLRP3-inflammasome in human macrophages in the presence of TLR stimulation

The paper shows that butyrate and propionate activate the NLRP3 inflammasome in human macrophages when combined with TLR agonists, through HDAC inhibition and epigenetic changes.

F420 reduction as a cellular driver for anaerobic ethanotrophy

This study identifies F420 reduction as a key driver in anaerobic ethanotrophy by characterizing archaeal enzymes and their structural interactions with F420-reductase modules.

Phytohormones regulate asexual Toxoplasma gondii

This study investigates how plant hormones affect the replication of Toxoplasma gondii tachyzoites in human cells, finding that abscisic acid promotes growth while gibberellic acid may inhibit it.

Food odours associated with conspecific corpses cause food avoidance in an invasive ant

This study shows that Argentine ants avoid food scented with conspecific corpses but not when corpses have ingested toxicant, suggesting potential strategies for bait management.

In situ structures from relaxed cardiac myofibrils reveal the organization of the muscle thick filament

This study reveals the 3D structure of relaxed cardiac sarcomeres using cryo-electron tomography, showing how thick filament components interact and function in muscle contraction.

Differences in the regulation mechanisms of the glutamine synthetase from methanogenic archaea unveiled by structural investigations

The paper compares regulation mechanisms of glutamine synthetase in two archaea, revealing distinct effector usage but a shared molecular switch for enzyme activity.

High resolution cryo-EM and crystallographic snapshots of the large actinobacterial 2-oxoglutarate dehydrogenase: an all-in-one fusion with unique properties

This paper presents high-resolution cryo-EM and crystallographic structures of the actinobacterial 2-oxoglutarate dehydrogenase OdhA, revealing its unique all-in-one architecture and regulatory mechanisms.

Specialized pathogenic cells release Tc toxins using a type 10 secretion system

The paper identifies a type 10 secretion system in Yersinia entomophaga that releases Tc toxins via controlled cell lysis, revealing a novel lytic mechanism for toxin export.

How a methanogen assimilates sulfate: Structural and functional elucidation of the complete sulfate-reduction pathway

This study elucidates the complete sulfate-reduction pathway in Methanothermococcus thermolithotrophicus, revealing non-canonical enzymes and a 'mix-and-match' evolutionary strategy for sulfate assimilation.

Transcriptomics sheds light on N2-fixation strategies employed by a thermophilic member of the Methanococcales

This paper studies nitrogen fixation in Methanothermococcus thermolithotrophicus, showing it relies on molybdenum and uses multiple strategies for nitrogen uptake while downregulating methanogenesis-related genes.

TomoTwin: Generalized 3D Localization of Macromolecules in Cryo-electron Tomograms with Structural Data Mining

TomoTwin is a deep learning model for automated macromolecule localization in cryo-electron tomograms without manual training data, using deep metric learning to embed structures in a high-dimensional space.

A systematic examination of learning in the invasive ant Linepithema humile reveals very rapid development of short and long-term memory

This study examines learning in Argentine ants, showing rapid short- and long-term memory development and efficient information transfer, suggesting potential for improving bait uptake in pest control.

The structure of the F420-dependent sulfite-detoxifying enzyme from Methanococcales reveals a prototypical sulfite-reductase with assimilatory traits.

This paper reports the X-ray structures of Fsr enzymes from two methanogens, revealing their unique architecture and electron transfer mechanism.

Structure of the thin filament in native skeletal muscles reveals its interaction with nebulin and two distinct conformations of myosin

The paper presents the first structure of native nebulin bound to thin filaments in sarcomeres, revealing interactions with actin and myosin conformations, and the molecular basis of nebulin's role in muscle function.

Rapid screening methods of potato cultivars for low glycemic traits

This study identifies potato cultivars with low amylopectin content using three methods, finding five promising cultivars with potential for low glycemic index.

Molecular plasticity of the native mouse skeletal sarcomere revealed by cryo-ET

This study uses cryo-ET to reveal the molecular architecture of mouse skeletal sarcomeres, showing detailed interactions and conformational plasticity in actin and myosin filaments.

TranSPHIRE: Automated and feedback-optimized on-the-fly processing for cryo-EM

TranSPHIRE automates cryo-EM data processing during acquisition, using a feedback loop to improve particle picking and produce high-resolution 3D reconstructions.

Two particle picking procedures for filamentous proteins: SPHIRE-crYOLO filament mode and SPHIRE-STRIPER

This paper introduces two methods for selecting filamentous proteins from cryo-EM images: a deep learning approach in SPHIRE-crYOLO and a line detection approach in SPHIRE-STRIPER, showing their performance on tobacco mosaic virus and F-actin datasets.

Large body size variation is linked to low communication success in tandem running ants

This study finds that larger body size differences between tandem running ants reduce communication success, with only 7% success when size variation exceeds 10%.

SPHIRE-crYOLO: A fast and accurate fully automated particle picker for cryo-EM

The paper introduces crYOLO, a deep learning-based particle picker for cryo-EM that achieves high accuracy and speed, enabling automated data pre-processing.