Author

D. Quentin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein structure prediction· 3 Assay:structural biology· 3 Organism:bacteria (other)· 2 Assay:cryo-EM· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Raunser· 5 shared C. Gatsogiannis· 2 shared F. Merino· 2 shared K. Sachar· 2 shared M. Stabrin· 2 shared O. Sitsel· 2 shared S. Ahmad· 2 shared A. Apelbaum· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersBiochemistry

S. Raunser

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Author profile →

5 papers

Recent·Most cited

Structure of a bacterial Rhs effector exported by the type VI secretion system

P. Guenther, D. Quentin, S. Ahmad, K. Sachar, C. Gatsogiannis, J. Whitney, S. Raunser

The paper presents the structure of the RhsA effector and its cognate VgrG1 spike protein from Pseudomonas protegens, revealing their assembly and potential mechanism of action via the T6SS.

bioRxiv · Sep 14, 2021Biochemistry

Structure of the human FERRY Rab5 effector complex

D. Quentin, J. Schuhmacher, B. U. Klink, J. Lauer, T. Shaikh, P. J. Huis in 't Veld, L. M. Welp, H. Urlaub, M. Zerial, S. Raunser

The paper determines the cryo-EM structure of the human FERRY Rab5 effector complex and shows Fy-2 acts as a binding hub for subunits and mRNA/Rab5.

bioRxiv · Jun 21, 2021 · PreprintBiochemistry

Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones

S. Ahmad, K. K. Tsang, K. Sachar, D. Quentin, T. M. Tashin, N. P. Bullen, S. Raunser, A. G. McArthur, G. Prehna, J. C. Whitney

The paper identifies a conserved motif in TMD-containing effectors and reveals how Eag chaperones stabilize these domains for T6SS-mediated secretion.

bioRxiv · Oct 28, 2020Biochemistry

Structural basis of TRPC4 regulation by calmodulin and pharmacological agents

D. Vinayagam, D. Quentin, O. Sitsel, F. Merino, M. Stabrin, O. Hofnagel, M. Yu, M. W. Ledeboer, G. Malojcic, S. Raunser

The paper reports structures of TRPC4 in complex with inhibitors, activators, and calmodulin, revealing how ligand binding and calmodulin interaction regulate the channel's conformation.

bioRxiv · Jun 30, 2020Biochemistry

SPHIRE-crYOLO: A fast and accurate fully automated particle picker for cryo-EM

T. Wagner, F. Merino, M. Stabrin, T. Moriya, C. Antoni, A. Apelbaum, P. Hagel, O. Sitsel, T. Raisch, D. Prumbaum, D. Quentin, D. Roderer, S. Tacke, B. Siebolds, E. Schubert, , S. Raunser

The paper introduces crYOLO, a deep learning-based particle picker for cryo-EM that achieves high accuracy and speed, enabling automated data pre-processing.

bioRxiv · Mar 13, 2019Biophysics