Author

P. Bieling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 4 Research Focus:chromatin & epigenetic regulation· 2 Approach:mechanistic / dynamical model· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein folding & dynamics· 2 Assay:ATAC-seq· 1 Approach:biophysical modeling· 1

Frequent Co-Authors

S. Raunser· 4 shared F. Merino· 3 shared J. Funk· 3 shared A. Belyy· 2 shared I. Visco· 2 shared A. Golding· 1 shared A. Roy· 1 shared B. Bardiaux· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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4 shared papersBiochemistry

S. Raunser

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Transient structural properties of the Rho GDP-dissociation inhibitor

S. M. Gomez, I. Visco, F. Merino, P. Bieling, R. Linser

This study reveals that the N-terminus of RhoGDI1 has preformed structural features in its free form, challenging the disorder-to-order transition model of GTPase inactivation.

bioRxiv · Sep 13, 2023 · PreprintBiophysics

Molecular mechanisms of inorganic-phosphate release from the core and barbed end of actin filaments

W. Oosterheert, F. Blanc, A. Roy, A. Belyy, O. Hofnagel, G. Hummer, P. Bieling, S. Raunser

This study identifies a molecular backdoor mechanism for inorganic phosphate release from actin filaments, showing how a disease-linked mutation alters Pi release rates and filament structure.

bioRxiv · Mar 25, 2023Biochemistry

Mechanism of threonine ADP-ribosylation of F-actin by a Tc toxin

A. Belyy, F. Lindemann, D. Roderer, J. Funk, B. Bardiaux, J. Protze, P. Bieling, H. Oschkinat, S. Raunser

This study reveals how TccC3 toxin modifies F-actin by ADP-ribosylating threonine-148, disrupting actin dynamics and causing cell death.

bioRxiv · May 6, 2022Biochemistry

The molecular mechanism of load adaptation by branched actin networks

T.-D. Li, P. Bieling, J. Weichsel, R. D. Mullins, D. A. Fletcher

This study investigates how applied forces affect branched actin network assembly, revealing that force alters nucleation and capping rates, increasing network density through a Brownian Ratchet mechanism.

bioRxiv · May 24, 2021Biophysics

A structure-derived mechanism reveals how capping protein promotes nucleation in branched actin networks

J. Funk, F. Merino, M. Schaks, K. Rottner, S. Raunser, P. Bieling

This study reveals how capping protein (CP) promotes nucleation in branched actin networks by controlling access to terminal actin subunits and inhibiting nucleation promoting factors.

bioRxiv · Mar 15, 2021Biochemistry

Profilin and formin constitute a pacemaker system for robust actin filament growth

J. Funk, F. Merino, L. Venkova, P. Vargas, S. Raunser, M. Piel, P. Bieling

This study shows that profilin and formin work together to control actin filament growth rates, making them resilient to changes in soluble actin concentrations.

bioRxiv · Aug 15, 2019Biochemistry

Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases

A. Golding, I. Visco, P. Bieling, W. Bement

The paper develops methods to image RhoGTPases in vivo and in vitro, revealing that RhoGDI actively extracts both active and inactive RhoGTPases, contributing to their spatial regulation around wounds.

bioRxiv · Aug 2, 2019Cell Biology