Macrophage inflammatory and regenerative response periodicity is programmed by cell cycle and chromatin state
B. Daniel, J. A. Belk, S. L. Meier, A. Y. Chen, K. Sandor, Y. Qi, H. Kitano, J. R. Wheeler, D. S. Foster, M. S. Januszyk, M. T. Longaker, H. Y. Chang, A. T. Satpathy
This study shows that macrophage inflammatory and regenerative responses are phase-dependent on the cell cycle, with S-G2/M phases linked to tissue remodeling and reduced IFNG-induced repolarization.
bioRxiv · Jun 24, 2021Immunology