R. Cheng

TSC22D, WNK and NRBP gene families exhibit functional buffering and evolved with Metazoa for macromolecular crowd sensing

This study identifies functional relationships between TSC22D, WNK, and NRBP gene families in macromolecular crowding sensing and cell volume regulation across metazoans.

Prokaryotic Gabija complex senses and executes nucleotide depletion and DNA cleavage for antiviral defense

The paper identifies the Gabija complex's mechanism of sensing nucleotide depletion and executing DNA cleavage for antiviral defense, showing its unique synergy between GajA and GajB.

Epidemiological evaluation and identification of the insect vector of soybean stay-green associated virus

This study identifies SoSGV as the causative agent of soybean stay-green syndrome and confirms the common brown leafhopper as its vector, revealing its epidemiology and geographical spread.

Coupled functional physiological phenotyping and simulation model to estimate dynamic water use efficiency and infer transpiration sensitivity traits

Viruses Diversity and Interactions with Hosts in Deep-Sea Hydrothermal Vents

This study characterizes viral diversity and host interactions in deep-sea hydrothermal vents, revealing novel viral lineages and metabolic roles in host adaptation.

Ubiquitin-like cGAS chain formation by a super enzyme activates anti-phage response

This study identifies a bacterial E2 enzyme that regulates cGAS by mimicking the ubiquitination cascade to activate anti-phage response through poly-cGASylation.

An intergeneric recombinant geminivirus causes soybean stay-green disease

This paper identifies a novel intergeneric recombinant geminivirus as the cause of soybean stay-green disease, showing it induces symptoms and can be detected in seed coats but not seeds.

Perinatal maternal chronic exposure to dibutyl phthalate promotes visceral obesity in adult female offspring

This study shows that maternal exposure to dibutyl phthalate during pregnancy and lactation leads to increased visceral obesity in adult female offspring without affecting serum glucolipid levels or the PI3K/AKT pathway in muscle.

The Unconventional Self-Cleavage of Selenoprotein K

This paper identifies selenok's self-cleavage activity and its specific interaction sites, suggesting a regulatory role in its protein interactions and cellular functions.

Development of a mini-replicon-based reverse-genetics system for rice stripe tenuivirus

This paper develops a mini-replicon-based reverse-genetics system for RSV, enabling functional analysis of its genes and host interactions in Nicotiana benthamiana.

Cytoplasmic and nuclear Sw-5b NLR act both independently and synergistically to dictate full host defense against tospovirus infection

This study shows that the tomato NLR Sw-5b acts in both cytoplasm and nucleus to provide full resistance against tospovirus by blocking different infection stages.

A nucleotide-sensing endonuclease from the Gabija bacterial defense system

This study identifies GajA as a nucleotide-regulated endonuclease from the Gabija bacterial defense system, which is inhibited by NTP and dNTP but activated during phage infection.

Divergent molecular signatures of regeneration and fibrosis during wound repair

This study identifies divergent molecular signatures of regeneration and fibrosis during wound repair using multimodal analysis.

Transferrin receptor is another receptor for SARS-CoV-2 entry

This study identifies the transferrin receptor (TfR) as an additional receptor for SARS-CoV-2 entry, showing that TfR-mediated infection can occur independently of ACE2 and that targeting TfR has anti-viral effects.

Transferrin-dependent crosstalk between the intestinal tract and commensal microbes contributes for immune tolerance

The paper shows that commensal microbes up-regulate host transferrin to suppress TLR signaling and promote immune tolerance in the gut.

Structure of S. pombe telomerase protein Pof8 C-terminal domain is an xRRM conserved among LARP7 proteins

This paper presents the X-ray crystal structure and NMR studies of S. pombe Pof8 RRM2, revealing it as an xRRM with conserved features for RNA binding and defining characteristics of the xRRM.

Iron-deficiency and estrogen are associated with ischemic stroke by up-regulating transferrin to induce hypercoagulability

The paper shows that iron-deficiency and estrogen increase transferrin, leading to hypercoagulability and worsened ischemic stroke.

Rescue of Tomato spotted wilt tospovirus entirely from cDNA clones, establishment of the first reverse genetics system for a segmented (-)RNA plant virus

This paper establishes the first reverse genetics system for a segmented negative-strand RNA plant virus, enabling molecular genetic analysis of its life cycle and pathogenicity.

The Typhoid Toxin Produced by the Nontyphoidal Salmonella Serovar Javiana Can Utilize Multiple Binding Subunits, which Compete for Inclusion in the Holotoxin

This study shows that S. Javiana's typhoid toxin uses multiple binding subunits that compete for inclusion in the holotoxin, enhancing toxin versatility.

A Genome-Wide Association Study of Non-Photochemical Quenching in response to local seasonal climates in Arabidopsis thaliana

This study identifies genetic loci associated with non-photochemical quenching in Arabidopsis thaliana under seasonal climate conditions using GWAS.

Seedling leaves allocate lower fractions of nitrogen to photosynthetic apparatus in nitrogen fixing trees (Dalbergia odorifera and Erythrophleum fordii) than in non-nitrogen fixing trees (Betula alnoides and Castanopsis hystrix) in subtropical China

The paper compares nitrogen allocation in leaves of nitrogen-fixing and non-nitrogen-fixing tree species, finding lower photosynthetic nitrogen use efficiency in nitrogen-fixing species due to reduced allocation to Rubisco and bioenergetics.