M. Griffin

Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter

This study reports the cryo-EM structure of a TRAP transporter from Haemophilus influenzae, revealing its dimeric architecture, Na+ sites, and substrate binding site, supported by mutagenic and functional data.

Piezo inhibition prevents and rescues scarring by targeting the adipocyte to fibroblast transition

This study shows that inhibiting Piezo1 or Piezo2 prevents adipocyte-to-fibroblast transition, reducing scarring in wounds and suggesting a therapeutic target for fibrosis.

Heritable and sex-specific variation in the development of social behavior in a wild primate

The paper examines heritable and sex-specific variation in the development of social behavior in wild baboons, finding early sex differences and weak heritability in grooming age.

Electric Field Responsive Nanotransducers for Glioblastoma

This paper investigates the use of gold, silica oxide, and zinc oxide nanoparticles to enhance the anticancer effects of electric fields on glioblastoma cells.

Extracellular Matrix Stiffness Alters TRPV4 Regulation in Chondrocytes

This study shows that softer cartilage substrates reduce TRPV4-mediated calcium influx and increase chondrocyte apoptosis, which can be mitigated by TRPV4 agonism.

Spatial-transcriptomics reveals unique defining molecular features of fluorescence-sorted 5-aminolevulinic acid+ infiltrative tumor cells associated with glioblastoma recurrence and poor survival

The paper uses spatial transcriptomics to identify molecular features of 5ALA+ infiltrative tumor cells in glioblastoma linked to recurrence and poor survival.

Divergent molecular signatures of regeneration and fibrosis during wound repair

This study identifies divergent molecular signatures of regeneration and fibrosis during wound repair using multimodal analysis.

DNA methylation and survival differences associated with the type of IDH mutation in 1p/19q non-codeleted astrocytomas

The paper shows that IDH mutations other than p.R132H in 1p/19q non-codeleted astrocytomas are linked to higher DNA methylation and better patient survival.

α1A-adrenoceptor inverse agonists and agonists modulate receptor signalling through a conformational selection mechanism

This study shows how different ligands modulate the conformational states of the α1A-adrenoceptor through a conformational selection mechanism, as revealed by NMR analysis of labeled receptor mutants.