An organoid platform reveals MEK-PARP co-targeting to enhance radiation response in rectal cancer
Q. Xiao, J. E. Riedesser, T. Mulholland, Z. Li, J. Buchloh, P. Albrecht, M. Li, N. Venkatachalam, O. Skabkina, A. Klupsch, E. Eichhorn, L. Wang, S. Belle, N. Schulte, D. Schmitz, , J. Betge
The paper uses a patient-derived rectal cancer organoid platform to identify MEK and PARP inhibitors that synergize with radiation to enhance treatment response in locally advanced rectal cancer.
bioRxiv · Jun 6, 2024 · PreprintCancer Biology