C.-C. D. Lee

Broadly neutralizing antibodies target the coronavirus fusion peptide

The paper identifies six monoclonal antibodies that broadly neutralize coronaviruses by targeting the conserved fusion peptide.

Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

The paper examines how mutations at E484 and K417 in SARS-CoV-2 variants affect neutralizing antibodies, showing reduced efficacy against certain antibody families but not others.

A combination of cross-neutralizing antibodies synergizes to prevent SARS-CoV-2 and SARS-CoV pseudovirus infection

This study shows that combining cross-neutralizing antibodies CV38-142 and COVA1-16 enhances neutralization of SARS-CoV-2 and SARS-CoV pseudoviruses.

Potent SARS-CoV-2 neutralizing antibodies selected from a human antibody library constructed decades ago

The paper identifies potent SARS-CoV-2 neutralizing antibodies from a pre-pandemic human antibody library, showing high somatic hypermutation and specific binding to the spike protein.

Evidence of antigenic imprinting in sequential Sarbecovirus immunization

This study shows that prior exposure to one Sarbecovirus strain biases antibody response to a subsequent, antigenically distinct strain, suggesting antigenic imprinting affects immunity to SARS-CoV-2.

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

This study identifies a single amino acid mutation that determines the difference in neutralization ability of a cross-reactive antibody between SARS-CoV-2 and SARS-CoV.

Structural basis of a public antibody response to SARS-CoV-2

The paper identifies IGHV3-53 as a common VH gene for SARS-CoV-2 neutralizing antibodies and determines its structural basis for binding the RBD.

A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model

This study identifies a potent SARS-CoV-2 neutralizing antibody that protects hamsters from infection and lung damage.

Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity

The paper identifies a SARS-CoV-2 antibody that cross-neutralizes SARS-CoV by binding a conserved epitope and relies on avidity for neutralization.

An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain

This study identifies an alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 RBD, showing that longer CDR H3 can bind with different angles and interactions.

An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen.

This paper identifies a small-molecule inhibitor of influenza A HA stem fusion using a fluorescence polarization screen and validates its antiviral activity against multiple H1N1 and H5N1 strains.

A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV

Structural study of a cross-reactive SARS antibody reveals a conserved epitope on the SARS-CoV-2 receptor-binding domain.