Author

D. Sharp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Dey· 2 shared A. Abdelrehim· 1 shared A. Jain· 1 shared A. Kramer· 1 shared A. Pal· 1 shared C. V. Rackauckas· 1 shared C. Zhang· 1 shared J. Biswas· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

A. Dey

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

mRNA Localization and Local Translation of the Microtubule Severing Enzyme, Fidgetin-Like 2, in Polarization, Migration and Outgrowth

R. Birnbaum, J. Biswas, R. Singer, D. Sharp

This study shows that mRNA localization and local translation of FL2 in protrusions drive its expression at the leading edge after injury, with IMP1 and let-7 miRNA regulating this process.

bioRxiv · Apr 17, 2023 · PreprintCell Biology

Stably Accelerating Stiff Quantitative Systems Pharmacology Models: Continuous-Time Echo State Networks as Implicit Machine Learning

R. Anantharaman, A. Abdelrehim, A. Jain, A. Pal, D. Sharp, U. Utkarsh, C. V. Rackauckas

This paper introduces continuous-time echo state networks (CTESNs) to accelerate stiff quantitative systems pharmacology models, achieving up to 56x speedup with <5% error.

bioRxiv · Oct 10, 2021Pharmacology & Toxicology

The kinesin-8 member Kif19 alters microtubule dynamics, suppresses cell adhesion, and promotes cancer cell invasion

S. Eisenberg, A. Dey, R. Brinbaum, D. Sharp

This study shows Kif19 promotes cancer cell invasion by altering microtubule dynamics and suppressing cell adhesion.

bioRxiv · Sep 4, 2020 · PreprintCell Biology

A Novel Therapeutic Approach to Corneal Alkaline Burn Model by Targeting Fidgetin-like 2, a Microtubule Regulator

J. Wang, A. Dey, A. Kramer, Y. Miao, J. Liu, L. Baker, J. Friedman, P. Nacharaju, R. S. Chuck, C. Zhang, D. Sharp

This paper evaluates FL2-NPsi, a nanoparticle-encapsulated siRNA targeting FL2, in a rat model of corneal alkaline burn, finding it enhances wound healing without toxicity.

bioRxiv · Jun 18, 2020Physiology